633314-21-3Relevant articles and documents
ROS-responsive and multifunctional anti-Alzheimer prodrugs: Tacrine-ibuprofen hybrids via a phenyl boronate linker
Liu, Zhikun,Zhang, Bin,Xia, Shengjin,Fang, Lei,Gou, Shaohua
, (2021)
Current drugs available in clinic for Alzheimer's disease (AD) treatment can only alleviate disease symptoms without clearly curing or delaying the process of AD. And some AD drugs failed in Phase III clinical trials are only focused on targeting amyloid-
H2O2-Responsive amphiphilic polymer with aggregation-induced emission (AIE) for DOX delivery and tumor therapy
Liang, Ya-Xuan,Sun, Xue-Yi,Xu, De-Zhong,Huang, Jun-Ru,Tang, Quan,Lu, Zhong-Lin,Liu, Rui
supporting information, (2021/12/27)
Stimuli-responsive drug delivery systems (DDSs) based on amphiphilic polymers have attracted much attention. In this study, we reported an innovative H2O2-responsive amphiphilic polymer (TBP), bearing a H2O2-sen
Multifunctional prodrug and derivative thereof, preparation method, pharmaceutical composition and application
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Paragraph 0040-0043, (2021/01/24)
The invention discloses a multifunctional prodrug and a derivative thereof, a preparation method, a pharmaceutical composition and application thereof. The chemical structure of the multifunctional prodrug is shown as a formula I, and the derivative of th
Lectin-Triggered Aggregation of Glyco-Gold Nanoprobes for Activity-based Sensing of Hydrogen Peroxide by the Naked Eye
Yeh, Che-Ming,Chen, Ming-Chun,Wu, Tzu-Chien,Chen, Jyun-Wei,Lai, Chian-Hui
, p. 3462 - 3468 (2021/09/16)
The purpose of this study was to develop a colorimetric assay for detecting hydrogen peroxide (H2O2) through a combination of using an aryl boronate (AB) derivative and gold nanoparticles (AuNPs). The unique optical property of AuNPs is applied to design a detection probe. The aggregation of AuNPs could be directly observed as a color change by the naked eye. A mannoside-boronate-sulfide (MBS) ligand was designed that contains an arylboronate (AB), a mannoside, and a thiol group. The thiol group bonds covalently with the surface of AuNPs to obtain MBS@AuNPs. The mannoside moiety recognizes concanavalin A (Con A), a lectin with four carbohydrate recognition sites that can specifically recognize the non-reducing end of an α-D-mannoside or α-D-glucoside structure. The AB structure on MBS first reacts with H2O2 and then inserts an oxygen atom in the B?H bond, which triggers intramolecular electron rearrangement to cleave the covalent bond, resulting in a MBSt mixture. The MBS or MBSt is then modified to citrate-coated AuNPs (c-AuNPs) to have MBS@AuNPs or MBSt@AuNPs. When the MBS@AuNPs are incubated with Con A, the Con A recognizes multiple mannosides on the surface of the MBS@AuNPs. Subsequently, the MBS@AuNPs aggregate and the solution's color changes from red to purple, but this color change does not occur in the case of MBSt@AuNPs. The phenomenon can be observed by the naked eye.
Antibiotic modified anticancer compounds for the treatment of non-genetic anti-cancer and anticancer pharmaceutical composition comprising the same
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Paragraph 0082-0085, (2021/08/05)
The present invention relates to an antibiotic modified anti-cancer compound for gene non-toxic anticancer therapy and an anticancer pharmaceutical composition comprising the same. A method for treating mitochondria target using a compound according to th
Self-Immolative Dye-Doped Polymeric Probe for Precisely Imaging Hydroxyl Radicals by Avoiding Leakage
Zhou, Yibo,Dong, Hao,Gu, Zhengxuan,Yang, Sheng,Ouyang, Minzhi,Qing, Zhihe,Ma, Xiaofei,Hu, Shan,Li, JunBin,Yang, Ronghua
, p. 12944 - 12953 (2021/10/02)
For sensing low abundance of biomarkers, utilizing nanocarriers to load dyes is an efficient method to amplify the detected signal. However, the non-specific leak of the internal dyes in this approach is accompanied by false positive signals, resulting in inaccurate signal acquirement. To address this issue, in this work, we reported a novel signal amplification strategy with dye as a scaffold to construct a self-immolative dye-doped polymeric probe (SDPP). In our proposed approach, the dyes were covalently integrated into the main chain of a polymer, which can avoid the non-specific leak of the dye when used in a rigorous biological environment, thus evading the false positive signal. As a prototype of this concept, a SDPP, which responds to hydroxyl radicals (?OH), was rationally fabricated. Upon being activated by?OH, SDPP will liberate the dye through a self-immolative reaction to bind with protein for amplifying the fluorescence signal. Compared with a dye-loaded nanoprobe, SDPP can precisely track intracellular basal?OH levels and visualize the?OH associated with myocarditis in vivo. More importantly, the attempt in this work not only provides an effective molecular tool to investigate the role of?OH in cardiopathy, but also puts forward a new direction to current signal-amplifying strategies for precisely and reliably acquiring the intracellular molecular information.
Mitochondrial Relocation of a Common Synthetic Antibiotic: A Non-genotoxic Approach to Cancer Therapy
Sunwoo, Kyoung,Won, Miae,Ko, Kyung-Phil,Choi, Miri,Arambula, Jonathan F.,Chi, Sung-Gil,Sessler, Jonathan L.,Verwilst, Peter,Kim, Jong Seung
supporting information, p. 1408 - 1419 (2020/04/15)
Tumor recurrence as a result of therapy-induced nuclear DNA lesions is a major issue in cancer treatment. Currently, only a few examples of potentially non-genotoxic drugs have been reported. Mitochondrial re-localization of ciprofloxacin, one of the most
Photo-thermal assistant penetration diagnosis and treatment type nanometer medicine (by machine translation)
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Paragraph 0082-0085, (2019/08/12)
The invention belongs to the technical field of biology, and particularly relates to a diagnosis and treatment drug for assisting in deep penetration of tumors by utilizing a photo-thermal effect. The in-situ released probe, under near-infrared illuminati
Selenium-containing paclitaxel dimer prodrug polymer nanoparticle and preparation method thereof
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Paragraph 0035; 0044, (2019/02/13)
The invention belongs to the field of pharmaceutical preparations, and relates to a selenium-containing paclitaxel dimer prodrug polymer nanoparticle and a preparation method thereof. The preparationis a selenium-containing paclitaxel dimer prodrug polymer nano-drug delivery system prepared from a selenium-containing paclitaxel dimer prodrug, a polyethylene glycol-polypolyphenylalanine amphiphilic polymer material, a polypeptide-modified polyethylene glycol-polyphenylalanine amphiphilic polymer material, and the like; the selenium-containing paclitaxel dimer prodrug polymer nano drug deliverysystem. The selenium-containing paclitaxel dimer prodrug is synthesized and encapsulated in the polyethylene glycol-polyphenylalanine amphiphilic polymer materials, by virtue of a special dimer structure, the high-drug-loading polymer nanoparticle0 is prepared, a Se-Se bond is introduced in the synthesis of the dimer prodrug, carrier stability can be effectively improved, and the controllable release of the drug in target cells can be realized; by modification of polypeptide molecules, the breast cancer targeting property of the nanoparticle can be obviously improved, the accumulation of thedrug is improved, and the anti-tumor effect of the drug is improved.
A self-immolative and DT-diaphorase-activatable prodrug for drug-release tracking and therapy
Li, Bowen,Liu, Peilian,Yan, Donghang,Zeng, Fang,Wu, Shuizhu
, p. 2635 - 2643 (2017/04/11)
DT-diaphorase, which catalyzes the reduction of various biological substances like quinones, is overexpressed in some malignant tumors. However, exploiting this attractive property for the controlled release of an active drug from a prodrug is yet to be fully taken advantage of. Herein we report a DT-diaphorase-based prodrug for concomitant drug-release imaging and cancer chemotherapy. This prodrug system is composed of two camptothecin (CPT) moieties as the active anticancer drug, a DT-diaphorase-responsive quinone propionic acid moiety and a set of self-immolative linkers. The presence of DT-diaphorase leads to the release of two CPT molecules and restores the fluorescence of the latter, thereby realizing the fluorescence monitoring of the DT-diaphorase level as well as the tracking of CPT release. Upon internalization by DT-diaphorase overexpressing cells, the prodrug can release fluorescent CPT and exhibit high cytotoxicity (half-maximal inhibitory concentration 0.71 μM) towards the cancer cells. This prodrug features on-demand enzyme-biomarker-triggered drug release as well as self-monitoring of drug release, therapeutic effect and biomarker level. This new strategy may provide an effective approach for constructing prodrugs with enhanced drug loading as well as controllability for drug release and tracking.
