633315-75-0Relevant academic research and scientific papers
Asymmetric Synthesis of Merck's Potent hNK1Antagonist and Its Stereoisomers via Tandem Acylation/[3,3]-Rearrangement of 1,2-Oxazine N-Oxides
Dorokhov, Valentin S.,Nelyubina, Yulia V.,Ioffe, Sema L.,Sukhorukov, Alexey Yu.
, p. 11060 - 11071 (2020/10/12)
An asymmetric total synthesis of Merck's hNK1 antagonist and three of its stereoisomers was accomplished in 10 steps. The synthesis involves a stereoselective assembly of 1,2-oxazine N-oxide by the [4 + 2]-cycloaddition, site-selective C-H oxygenation usi
Synthesis of (±)- and (-)-botryodiplodin using stereoselective radical cyclizations of acyclic esters and acetals
Nouguier, Robert,Gastaldi, Stephane,Stien, Didier,Bertrand, Michele,Villar, Felix,Andrey, Olivier,Renaud, Philippe
, p. 3005 - 3018 (2007/10/03)
Three different routes for the stereoselective synthesis of botryodiplodin have been investigated. The intramolecular allylation of acetals proved to be unsatisfactory due to unstable intermediates and poor stereocontrol. Zard intramolecular radical allyl
