633316-63-9Relevant academic research and scientific papers
Phenylcyclobutyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type I
Zhu, Yuping,Olson, Steven H.,Graham, Donald,Patel, Gool,Hermanowski-Vosatka, Anne,Mundt, Steven,Shah, Kashmira,Springer, Marty,Thieringer, Rolf,Wright, Samuel,Xiao, Jianying,Zokian, Hratch,Dragovic, Jasminka,Balkovec, James M.
body text, p. 3412 - 3416 (2009/04/06)
3-(Phenylcyclobutyl)-1,2,4-triazoles were identified as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). These were active both in vitro and in an in vivo mouse pharmacodynamic (PD) model. Fluorine substitution of the cyclobutan
11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 INHIBITORS USEFUL FOR THE TREATMENT OF DIABETES, OBESITY AND DYSLIPIDEMIA
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Page 32-40, (2010/02/05)
Compounds having Formula (I), including pharmaceutically acceptable salts, hydrates and solvates thereof, are selective inhibitors of the 11β-HSD1 enzyme. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dylsipidemia, hyperlipidemia, hypertension, Syndrome X, and other symptoms associated with NIDDM.
