6334-36-7Relevant academic research and scientific papers
A 5 - amino acetyl propionic acid hydrochloride intermediate environmental preparation method
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Paragraph 0021-0022; 0024-0026; 0028, (2019/07/01)
The invention discloses a 5 - amino acetyl propionic acid hydrochloride intermediate environmental preparation method, the method using a compound represented by the structural formula I and II shown in the structural formula of the compound as a raw material, wherein R1 , R2 , R3 Represents hydrogen, methyl, ethoxy or methoxy, R4 Represents hydrogen, potassium or sodium, by condensation reaction and supported bi-reaction to obtain 5 - amino acetyl propionic acid hydrochloride salt intermediate. The preparation method is simple, the reaction process and after-reaction of the post-treatment process to avoid the use of water, the washing process without need of extraction, high yield, compared with the traditional method, greatly reduces the production of waste water, more green environmental protection, is favorable for industrial production.
Preparation methods for 5-aminolevulinic acid hydrochloride and 5-aminolevulinic acid hydrochloride intermediate
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Paragraph 0083; 0084; 0087, (2018/09/11)
The invention discloses preparation methods for a 5-aminolevulinic acid hydrochloride and a 5-aminolevulinic acid hydrochloride intermediate. The preparation method for the 5-aminolevulinic acid hydrochloride intermediate comprises: (1) carrying out a reaction on a compound 2 and isopropylidene malonate in an organic solvent under the actions of an organic alkali and a condensing agent to obtain acompound 3; and (2) carrying out a reaction on the compound 3 in a C1-C4 alcohol solvent to obtain a compound 4, wherein R1 and R' are respectively and independently C1-C4 alkyl. The present invention further provides a method for preparing a 5-aminolevulinic acid hydrochloride by using the 5-aminolevulinic acid hydrochloride intermediate. According to the present invention, the intermediate product is basically solid and is easily crystallized and purified; and the method has characteristics of high yield, low production cost and easy operation, and is suitable for industrial production. Thecompounds 1, 2, 3 and 4 are defined in the specification.
Enantioselective syntheses of 1-carbacephalosporins from chemoenzymically derived β-hydroxy-α-amino acids: Applications to the total synthesis of carbacephem antibiotic loracarbef
Jackson, Billy G.,Pedersen, Steve W.,Fisher, Jack W.,Misner, Jerry W.,Gardner, John P.,Staszak, Michael A.,Doecke, Christopher,Rizzo, John,Aikins, James,Farkas, Eugene,Trinkle, Kristina L.,Vicenzi, Jeffrey,Reinhard, Matt,Kroeff, Eugene P.,Higginbotham, Chris A.,Gazak,Zhang, Tony Y.
, p. 5667 - 5677 (2007/10/03)
Serine hydroxymethyltransferase (SHMT) derived from recombinant E. coli was found to be able to catalyze the condensation between glycine and 4-pentenaldehyde, affording enantiopure L-erythro-2-amino-3-hydroxy-6-heptenoic acid (AHHA) in high yield and throughput. Conversion of this chiral intermediate of biosynthetic origin to the oral carbacephalosporin antibiotic loracarbef (Lorabid) via β-lactam forming reactions and subsequent Dieckmann cyclization was achieved. (C) 2000 Elsevier Science Ltd.
Convenient syntheses of δ-aminolevulinic acid
Nudelman, Ayelet,Nudelman, Abraham
, p. 568 - 570 (2007/10/03)
Two convenient procedures for the synthesis of δ-aminolevulinic acid (5-ALA) are described.
