63348-68-5Relevant academic research and scientific papers
Pd-Catalyzed direct C-H functionalization of imidazolones with aryl- and alkenyl halides
Muselli, Mickal,Baudequin, Christine,Hoarau, Christophe,Bischoff, Laurent
, p. 745 - 748 (2015)
Direct C-H arylation and alkenylation of 4,4′-dialkylimidazolones with a broad range of halides under palladium and copper catalysis have been developed. This methodology is applied to the preparation of recently discovered fatty acid synthetase (FAS) inhibitors. This journal is
Mild, Efficient, One-Pot Synthesis of Imidazolones Promoted by N,O-Bistrimethylsilylacetamide (BSA)
Muselli, Micka?l,Colombeau, Ludovic,Hédouin, Jonathan,Hoarau, Christophe,Bischoff, Laurent
, p. 2819 - 2825 (2016/12/14)
The formation of imidazolones by means of dehydrative cyclization was developed, using bistrimethylsilylacetamide. This highly versatile, friendly, safe, and cost-effective reagent exhibited a very large scope of starting materials, since it can promote the formation of 4-benzylidene imidazolones, 4,4-dialkyl-imidazolones, bearing alkyl, aryl, or even no substituent at C2, the latter being unavailable by classical methods. This reagent also afforded clean and high-yielding one-pot reactions in the presence of amine or imine reagents.
IMIDAZOPYRIDAZINES USEFUL AS INHIBITORS OF THE PAR-2 SIGNALING PATHWAY
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Paragraph 00328, (2015/04/15)
The present invention relates to compounds useful as inhibitors of the PAR-2 signaling pathway. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, dis
