6335-97-3Relevant academic research and scientific papers
Oxone-sodium nitrite mediated N-nitrosamines formation under mild conditions from secondary amines
Gaur, Pinki,Banerjee, Shaibal
, p. 2270 - 2279 (2019/07/03)
Herein, we report an efficient synthesis of N-nitrosamines from cyclic, aliphatic, benzylic, and aromatic secondary amines via a novel straightforward, efficient, and mild chemical process using sodium nitrite and Oxone in methanol as a solvent at 0–5 °C. The demonstrated methodology accounts well for the parameters like cost-effective, short reaction time, clean and safe handling along with good to excellent yields.
Iodide-catalyzed synthesis of N-nitrosamines via C-N cleavage of nitromethane
Zhang, Jie,Jiang, Jiewen,Li, Yuling,Wan, Xiaobing
, p. 11366 - 11372 (2013/12/04)
An iodide-catalyzed process to synthesize N-nitrosamines has been developed using TBHP as the oxidant. The mild catalytic system succeeded in cleaving the carbon-nitrogen bond in nitromethane. This methodology uses commercially available, inexpensive catalysts and oxidants and has a wide substrate scope and operational simplicity.
