63352-68-1

Upstream product

• 936-59-4 3-chloropropiophenone 
• 95-51-2 o-chloroaniline 
• 71-43-2 benzene 
• 768-03-6 Phenyl vinyl ketone 
• 5409-66-5 3-benzoyl-4-hydroxy-1-methyl-4-phenylpiperidine 
• 879-72-1 3-(dimethylamino)propiophenone hydrochloride 

Downstream Products

• 78994-07-7 2-Chloro-3-(2-chloro-phenyl)-6-phenyl-3,4-dihydro-[1,3,2]oxazaphosphinine 2-oxide 

Relevant academic research and scientific papers

I2-Promoted Intramolecular Oxidative Cyclization of Butenyl Anilines: A Facile Route to Benzo[b]azepines

A metal-free approach for the synthesis of seven-membered N-heterocycles has been developed by the I2-promoted intramolecular cross-coupling/annulation of butenyl anilines. This cyclization reaction involves C?H activation and C?C bond formation and exhibits good functional group tolerance. A series of benzo[b]azepine derivatives are obtained in moderate to good yields.

Aza-Michael reaction promoted by aqueous sodium carbonate solution

A general and efficient aza-Michael reaction promoted by aqueous sodium carbonate solution has been developed. The reaction has complete mono-alkylation selectivity and proceeds with complete chirality retention for chiral amino esters. With a broad substrate scope, a well-common catalyst and simple operation, the catalytic approach provides a facile, practicable, economical, and environmentally benign method for the synthesis of β-amino carbonyl compounds.

Conversion of 3-benzoyl-1-methyl-4-phenyl-γ-piperidol by arylamines and arylhydrazines. Synthesis of 3-arylamino-1-oxo-1-phenylpropanes and 1,3-diarylpyrazoles and their fragmentation under electron impact

It has been established that on heating, 3-benzoyl-4-hydroxy-1-methyl-4- phenylpiperidine is ring-opened in the presence of arylamines by a type of retroaldol reaction, with subsequent transamination of the intermediate Mannich base and the formation of 3-arylamino-1-oxo-1-phenylpropanes. When using arylhydrazines this γ-piperidol is recyclized with the formation of 1,3-diarylpyrazoles and their 4,5-dihydro derivatives. The mass spectral behavior of a series of 3-arylamino-substituted 1-phenylpropanones has been studied.

Reaction of 3-benzoyl-1-methyl-4-phenyl-γ-piperidol with arylamines and arylhydrazines. Synthesis of 3-arylamino-1-oxo-1-phenylpropanes and 1,3 diarylpyrazoles and their fragmentation under electron impact

Upon heating in the presence of arylamines 3-benzoyl-4-hydroxy-1-methyl-4- phenylpiperidine decyclizes via a retroaldol type reaction with subsequent transamination of the intermediate Mannich base to give 3-arylamino-1-oxo-1- phenylpropanes. In the case of the use of arylhydrazines this γ-piperidol recyclizes to give 1,3-diarylpyrazoles and their 4,5-dihydro derivatives. The mass spectroscopic behavior of a series of 3-arylamino-substituted 1-phenylpropanones has been studied.

Synthesis of Heterocyclic Compounds: Part XXVI - 3,6-Diaryl-3,4-dihydro-1,3,2-oxazaphosphorin-2-oxides

3,4-Dihydro-1,3,2-oxazaphosphorin-2-oxides (4a-r) have been prepared by the interaction of aryl β-aryl/alkylaminoethyl ketones (3a-r) with POCl3/Et3N.Various reactions of these compounds, which represent a new ring system, are reported.Few of these compou

Synthesis and Reactions of 3,6-Diaryl-3,4-dihydro-1,3,2-oxazaphosphorin-2-oxides

Aryl β-arylaminoethyl ketones (1), when reacted with phosphorus oxychloride followed by treatment with triethylamine, afford 3,6-diaryl-2-chloro-3,4-dihydro-1,3,2-oxazaphosphorin-2-oxides (3a-u), a hitherto unreported ring system.The oxazaphosphorin (3q), viz. 2-chloro-3-m-anisyl-6-phenyl-3,4-dihydro-1,3,2-oxazaphosphorin, is converted into 7-methoxy-4-phenylquinoline on keeping.This transformation is specific to 3q since other oxazaphosphorins fail to give the quinoline derivative.