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6-Chloro-2-(2-chlorophenyl)-2,3-dihydro-4H-chromen-4-one is a complex organic chemical compound with the molecular formula C15H10Cl2O2. It is a derivative of the naturally occurring flavonoid, flavone, and is characterized by the presence of a 6-chloro group and a 2-chlorophenyl group. 6-chloro-2-(2-chlorophenyl)-2,3-dihydro-4H-chromen-4-one is a yellow crystalline solid and is soluble in organic solvents. It has potential applications in the pharmaceutical industry, particularly as a precursor in the synthesis of various drugs and bioactive compounds. Due to its complex structure and potential reactivity, it is important to handle this chemical with care and in accordance with proper safety protocols.

6336-06-7

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6336-06-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 6336-06-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,3 and 6 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 6336-06:
(6*6)+(5*3)+(4*3)+(3*6)+(2*0)+(1*6)=87
87 % 10 = 7
So 6336-06-7 is a valid CAS Registry Number.

6336-06-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-chloro-2-(2-chlorophenyl)-2,3-dihydrochromen-4-one

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:6336-06-7 SDS

6336-06-7Downstream Products

6336-06-7Relevant academic research and scientific papers

Halogenated flavanones as potential apoptosis-inducing agents: Synthesis and biological activity evaluation

Safavi, Maliheh,Esmati, Nasim,Ardestani, Sussan Kabudanian,Emami, Saeed,Ajdari, Soheila,Davoodi, Jamshid,Shafiee, Abbas,Foroumadi, Alireza

, p. 573 - 580 (2013/02/21)

A series of halogenated flavanones were synthesized from 2-hydroxychalcones and tested for their cytotoxicity against a panel of human cancer cell lines. Among the synthesized compounds, 3′,7-dichloroflavanone (2d) showed the highest activity against MCF-7, LNCaP, PC3, Hep-G2, KB and SK-N-MC cells. However, 3′,6-dichloroflavanone (2g) with IC50 value of 2.9 ± 0.9 μM was the most potent compound against MDA-MB-231 cells, being approximately 12 times more active than etoposide as reference drug. According to the flow-cytometric analysis, compound 2g can induce apoptosis by 66.19 and 21.37% in PC3 and MDA-MB-231 cells, respectively. The results of acridine orange/ethidium bromide staining and TUNEL assay suggested that the cytotoxic activity of this compound in PC3 and MDA-MB-231 cells occurs via apoptosis.

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