6338-70-1

Usage

Uses

Used in Pharmaceutical Industry:
3-aminosulfolane is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and ability to form hydrogen bonds make it a valuable component in the development of new drugs.
Used in Drug Production:
3-aminosulfolane is used as a building block in the production of certain drugs, contributing to their chemical structure and potential therapeutic effects. Its presence in these compounds may enhance their efficacy and help address specific medical needs.

InChI:InChI=1/C4H9NO2S/c5-4-1-2-8(6,7)3-4/h4H,1-3,5H2/p+1/t4-/m1/s1

Upstream product

• 77-79-2 3-Sulfolene 

Downstream Products

• 68992-07-4 tetrahydro-N,N-bis(phosphonomethyl)-3-thiophenamine 1,1-dioxide 
• 1424996-19-9 C₂₉H₃₂N₂O₅S 
• 1196452-25-1 3-[5-({(1R,2S)-2-[(2,2-difluoropropanoyl)amino]-1-phenylpropyl}oxy)-1H-indazol-1-yl]-N-(1,1-dioxidotetrahydrothiophen-3-yl)benzamide 
• 1352451-97-8 1-(3-chloropyridin-2-yl)-N-{4-cyano-2-[(1,1-dioxidotetrahydrothiophen-3-yl)carbamoyl]-6-methylphenyl}-3-{[5-(trifluoromethyl)-2H-tetrazol-2-yl]methyl}-1H-pyrazole-5-carboxamide 
• 1344706-35-9 2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)-N-(3,3-dioxide-tetrahydrothiophen-3-yl)acetamide 
• 1344706-41-7 (R/S)-2-hydroxy-N-(2-oxo-2-(1,1-dioxide-tetrahydrothiophen-3-ylamino)ethyl)-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide 
• 1246779-24-7 (1R,3aS,3bS,10aR,10bS,11S,12aS)-7-{3-[(1,1-dioxidotetrahydrothiophen-3-yl)carbamoyl]phenyl}-11-hydroxy-10a,12a-dimethyl-1-(propanoyloxy)-1,2,3,3a,3b,4,5,7,10,10a,10b,11,12,12a-tetradecahydrocyclopenta[5,6]naphtho[1,2-f]indazole-1-carboxylic acid 
• 946385-19-9 3-(4-methoxyphenyl)-9-(1,1-dioxytetrahydrothien-3-yl)-9,10-dihydro-4H,8H-chromeno[8,7-e][1,3]oxazin-4-one 
• 1196452-35-3 3-(5-{[(1R,2S)-2-[(2,2-difluoropropanoyl)amino]-1-(6-methoxypyridin-3-yl)propyl]oxy}-1H-indazol-1-yl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)benzamide 
• 1089669-65-7 5-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(1,1-dioxidotetrahydro-3-thienyl)-2-thiophenesulfonamide 
• 923292-90-4 4-(1,1-Dioxotetrahydrothiophen-3-ylamino)-2-methylsulfanylpyrimidine-5-carboxylic acid (4-fluorophenyl)amide 

Relevant academic research and scientific papers

Synthesis of potassium (1,1-dioxothiolan-3-yl)-dithiocarbamate

A method of synthesizing bioactive potassium (1,1-dioxothiolan-3-yl) dithiocarbamate in high yield and purity is reported.

PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS

The invention relates to a compound of formula (I) or a salt thereof: wherein:R1 is C1-4alkyl, C1-3fluoroalkyl, -CH2CH2OH or -CH2CH2CO2C1-2alkyl;R2 is a hydrogen atom (H), methyl or C1fluoroalkyl;R3 is optionally substituted C3-8cycloalkyl or optionally substituted mono-unsaturated-C5-7cycloalkenyl or an optionally substituted heterocyclic group of sub-formula (aa), (bb) or (cc); in which n1 and n2 independently are 1 or 2; and in which Y is O, S, SO2, or NR10; or R3 is a bicyclic group (dd) or (ee): ; and wherein X is NR4R5 or OR5a. The compounds are phosphodiesterase (PDE) inhibitors, in particular PDE4 inhibitors. Also provided is the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment and/or prophylaxis of an inflammatory and/or allergic disease in a mammal such as a human, for example chronic obstructive pulmonary disease (COPD), asthma, or allergic rhinitis.