6339-79-3

Basic information

• Product Name: 4-Thiazolidinone, 5-[(4-hydroxyphenyl)methylene]-2-thioxo-
• Synonyms: 4-Thiazolidinone, 5-[(4-hydroxyphenyl)methylene]-2-thioxo-
• CAS NO: 6339-79-3
• Molecular Formula: C₁₀H₇NO₂S₂
• Molecular Weight: 237.3
• Mol File: 6339-79-3.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Density: 1.56g/cm³
• Refractive Index: 1.776
• CAS DataBase Reference: 4-Thiazolidinone, 5-[(4-hydroxyphenyl)methylene]-2-thioxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Thiazolidinone, 5-[(4-hydroxyphenyl)methylene]-2-thioxo-(6339-79-3)
• EPA Substance Registry System: 4-Thiazolidinone, 5-[(4-hydroxyphenyl)methylene]-2-thioxo-(6339-79-3)

Safety Data

• Hazardous Substances Data: 6339-79-3(Hazardous Substances Data)

Usage

General Description

4-Thiazolidinone, 5-[(4-hydroxyphenyl)methylene]-2-thioxo- is a chemical compound with a 4-thiazolidinone ring and a hydroxyphenyl group. It has a thione functional group and is used as a building block in the synthesis of various organic compounds. This chemical has potential applications in the pharmaceutical and agrochemical industries for the development of novel drugs and pesticides. Its unique structure and reactivity make it a valuable tool for the creation of diverse molecular structures with potential biological activities. Additionally, it may also have potential applications in material science and other industrial processes.

InChI:InChI=1/C10H7NO2S2/c12-7-3-1-6(2-4-7)5-8-9(13)11-10(14)15-8/h1-5,12H,(H,11,13,14)

Upstream product

• 141-84-4 2-thioxo-4-thiazolidinone 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 339283-50-0 (4-acetyloxyphenyl)methylene-2-thioxo-4-thiazolidinone 
• 64449-50-9 methyl 3-p-hydroxyphenyl-2-mercaptoacrylate 
• 29529-80-4 3-(4-hydroxyphenyl)-2-sulfanylpropenoic acid 

Relevant articles and documents

Solid acid TS-1 catalyst: an efficient catalyst in Knoevenagel condensation for the synthesis of 5-arylidene-2,4-thiazolidinediones/Rhodanines in aqueous medium

Abstract: TS-1 zeolite was prepared for the synthesis of 5-arylidene-2,4-thiazolidinediones/Rhodanines in aqueous medium by incorporating titanium(IV) cations in a silicate-1 framework using hydrothermal treatment and characterized by using XRD, EDX, BET, FT-IR and SEM techniques. The catalytic activity of the catalyst was tested for Knoevenagel condensation reaction. The condensation of active ethylene 2,4-thiazolidinedione with substituted aryl aldehydes under aqueous medium at 90?°C afforded the corresponding product in excellent yield up to 92% within 30?min. The present method offers several advantages over the reported methods such as easy separation of catalyst, simple work-up procedure, and an excellent yield of desired product. Furthermore, the catalyst could be reused without significant loss in activity. Graphical abstract: [Figure not available: see fulltext.]

Synthesis of 5-Alkylidene-2,4-thiazolidinediones and Rhodanines Promoted by Propylamino-functionalized Nano-structured SBA-15

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Urea/thiourea catalyzed, solvent-free synthesis of 5-arylidenethiazolidine- 2,4-diones and 5-arylidene-2-thioxothiazolidin-4-ones

An efficient and organo-catalyzed method has been developed for the synthesis of 5-arylidenethiazolidine-2,4-diones and 5-arylidene-2- thioxothiazolidin-4-ones via Knoevenagel condensation of arylaldehydes 1 and 2,4-thiazolidinedione 2a/2-thioxothiazolidin-4-one 2b under mild conditions. Urea-adduct 4 and azomethine 5 also afford arylidene-products 3 by reacting with 2a-b via addition-elimination reaction. This protocol has the features of use of inexpensive, ecofriendly readily available, effective catalyst system viz. urea/thiourea, avoidance of volatile solvents, excellent yield and simple work-up procedure.