63393-92-0

Basic information

• Product Name: cremophor EL
• Synonyms: Fatty acids, castor-oil, esters with ethoxylated glycerol
• CAS NO: 63393-92-0
• Molecular Formula: C5H12O4
• Molecular Weight: 136.14638
• Mol File: 63393-92-0.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 290°C at 760 mmHg
• Flash Point: 160°C
• Appearance: /
• Vapor Pressure: 0.000232mmHg at 25°C
• CAS DataBase Reference: cremophor EL(CAS DataBase Reference)
• NIST Chemistry Reference: cremophor EL(63393-92-0)
• EPA Substance Registry System: cremophor EL(63393-92-0)

Safety Data

• Hazardous Substances Data: 63393-92-0(Hazardous Substances Data)

Usage

Description

Cremophor EL is a nonionic surfactant and solubilizer that is commonly used in pharmaceuticals, cosmetics, and food products. It is a clear, colorless liquid derived from castor oil and ethylene oxide, known for its ability to solubilize poorly water-soluble drugs and enhance their bioavailability.
Used in Pharmaceutical Industry:
Cremophor EL is used as a solubilizer for poorly water-soluble drugs to improve their bioavailability and enhance their therapeutic effects.
Used in Cosmetics Industry:
Cremophor EL is used as an emulsifier and stabilizer in cosmetic products to create stable emulsions and improve the texture and appearance of the products.
Used in Food Industry:
Cremophor EL is used as an emulsifier and stabilizer in food products to improve the texture, stability, and shelf life of the products.
However, it has been associated with certain side effects and potential toxicities, particularly when used in high doses, including hypersensitivity reactions and effects on the immune system. As a result, its use in certain pharmaceutical formulations has been limited or modified to reduce the risk of adverse effects.

InChI:InChI=1/C3H8O3.C2H4O/c4-1-3(6)2-5;1-2-3-1/h3-6H,1-2H2;1-2H2