634-25-3 Usage
Description
4-Pyridinecarboxaldehyde, 3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-, oxime is an organic compound that contains the C:NOH group. It is formed by the reaction of an aldehyde or ketone with hydroxylamine (NH2OH).
Uses
Used in Pharmaceutical Industry:
4-Pyridinecarboxaldehyde, 3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-, oxime is used as a pharmaceutical intermediate for the synthesis of various drugs and drug candidates. Its unique structure and functional groups make it a versatile building block in the development of new therapeutic agents.
Used in Chemical Research:
4-Pyridinecarboxaldehyde, 3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-, oxime is used as a research compound in various chemical studies. Its reactivity and structural features allow scientists to explore its potential applications in the synthesis of new compounds and materials.
Used in Analytical Chemistry:
4-Pyridinecarboxaldehyde, 3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-, oxime can be used as a derivatizing agent in analytical chemistry. Its ability to form adducts with various analytes makes it a useful tool for enhancing the detection and quantification of target compounds in complex samples.
Check Digit Verification of cas no
The CAS Registry Mumber 634-25-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,3 and 4 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 634-25:
(5*6)+(4*3)+(3*4)+(2*2)+(1*5)=63
63 % 10 = 3
So 634-25-3 is a valid CAS Registry Number.
634-25-3Relevant articles and documents
Hydroxamic acids as a novel family of serine racemase inhibitors: Mechanistic analysis reveals different modes of interaction with the pyridoxal-5′-phosphate cofactor
Hoffman, Hillary E.,Jirásková, Jana,Cígler, Petr,?anda, Miloslav,Schraml, Jan,Konvalinka, Jan
, p. 6032 - 6041 (2009)
Mammalian serine racemase (SR) is a pyridoxal-5′-phosphate (PLP) dependent enzyme responsible for the biosynthesis of the neurotransmitter D-serine, which activates N-methyl-D-aspartate (NMDA) receptors in the CNS. Aberrant regulation of NMDA receptor signaling has been implicated in a variety of neuropathologies, and inhibitors of SR would therefore be a worthwhile tool for further investigation or treatment of such conditions. Here, we identify a series of small aliphatic hydroxamic acids (HAs) that act as potent SR inhibitors. However, specificity studies showed that some of these HAs can act as nonspecific inhibitors of PLP-dependent enzymes. We employed NMR, MS, and UV/vis spectroscopic techniques to reveal that the nonspecific effect is likely due to irreversible interaction of the HA moiety with PLP to form aldoxime species. We also characterize L-aspartic acid β-hydroxamate as a competitive and selective SR inhibitor that could be used as a scaffold for further inhibitor development. 2009 American Chemical Society.
