6340-49-4

Usage

Uses

Used in Organic Synthesis:
1-(2-methylbut-3-yn-2-yl)piperidine is used as a building block for the synthesis of more complex organic molecules. Its unique structure allows for further chemical reactions and modifications, making it a valuable component in the creation of novel compounds with specific properties and functions.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-(2-methylbut-3-yn-2-yl)piperidine is used as a starting material for the development of new pharmaceuticals. Its structural diversity and reactivity enable the design and synthesis of potential drug candidates with improved efficacy and selectivity.
Used in Research Applications:
1-(2-methylbut-3-yn-2-yl)piperidine is also utilized in various research applications, including the study of its chemical properties, reactivity, and potential interactions with biological systems. This knowledge can contribute to the understanding of its potential uses in different industries and the development of new applications.
It is crucial to handle 1-(2-methylbut-3-yn-2-yl)piperidine with care, adhering to proper safety protocols and procedures to ensure the safety of researchers and the environment.

Upstream product

• 110-89-4 piperidine 
• 1111-97-3 3-chloro-3-methylbut-1-yne 
• 6214-31-9 3-bromo-3-methylbut-1-yne 

Downstream Products

• 144776-79-4 2-(dimethylphenylsilylmethyl)-3-methyl-2-butenal 

Relevant academic research and scientific papers

Aldehyde dehydrogenase inhibitors: α,β-Acetylenic N-substituted aminothiolesters are reversible growth inhibitors of normal epithelial but irreversible apoptogens for cancer epithelial cells from human prostate in culture

The pharmacomodulation of the N atom of α,β-acetylenic aminothiolesters or the replacement of the thiolester moiety by more electrophilic groups did not permit any clear rationale to be established for improving the selective growth-inhibitory activity of this family of compounds over that of the previously synthesized α,β-acetylenic aminothiolesters DIMATE and MATE [G. Quash, G. Fournet, J. Chantepie, J. Gore, C. Ardiet, D. Ardail, Y. Michal, U. Reichert, Biochem Pharmacol 64 (2002) 1279-92]. Hence DIMATE and MATE were investigated more thoroughly for selectivity and growth-inhibitory activity using human prostate epithelial normal cells (HPENC) on the one hand and human prostate epithelial cancer cells (DU145) on the other. Unequivocal evidence was obtained showing that both compounds were reversible growth inhibitors of HPENC but irreversible growth inhibitors of DU145. Growth-inhibition of DU145 was due to the induction of early apoptosis as revealed by the flow cytometric analytical profile of inhibitor-treated cells, of the decrease in the redox potential and increase in superoxide anion content of their mitochondria. Of the two intracellular enzymes: aldehyde dehydrogenases 1 and 3 (ALDH1 and ALDH3) targeted by DIMATE and MATE, ALDH3 was inhibited to the same extent by both compounds whereas ALDH1 was less susceptible to inhibition by MATE. As the induction of ALDH3 by xenobiotics is hormone-dependent, MATE, the more selective of the two inhibitors, is a useful tool not only for examining the role of the ALDH3 isoform in hormone-sensitive and resistant prostate cancer cells in culture but also for investigating if it can inhibit the growth of xenografts of prostate cancer in immunodeficient mice.

Heterobicyclic thiophene compounds and methods of use

Compounds of Formula I and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula I and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Indole and dihydroindole derivatives

The present invention relates to indole derivatives, dihydroindole derivatives and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.

REACTIONS OF NITROGEN NUCLEOPHILES WITH 1-BROMOALLENES: REGIOSELECTIVE SYNTHESIS OF PROPARGYLAMINES

The results of a study on the reactivity of 3-alkyl- and 3,3-dialkyl-1-bromo-1,2-dienes 2 towards nitrogen nucleophiles, such as aqueous ammonia, lithium amide, aliphatic and aromatic amines allowed us to propose new methods for the synthesis of propargylamines, 1, with an available acetylenic hydrogen.The regio- and the stereoselectivity of these reactions are examined and possible mechanisms are discussed.