6340-89-2

Basic information

• Product Name: (5Z)-5-(2-chloro-6-fluorobenzylidene)-3-methyl-1,3-thiazolidine-2,4-dione
• CAS NO: 6340-89-2
• Molecular Formula: C₂₅H₂₁N₃O₂
• Molecular Weight: 271.6952
• Mol File: 6340-89-2.mol
• Article Data: 50

Chemical Properties

• Boiling Point: 379.4°C at 760 mmHg
• Flash Point: 183.3°C
• Density: 1.542g/cm³
• Vapor Pressure: 5.87E-06mmHg at 25°C
• Refractive Index: 1.673
• CAS DataBase Reference: (5Z)-5-(2-chloro-6-fluorobenzylidene)-3-methyl-1,3-thiazolidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (5Z)-5-(2-chloro-6-fluorobenzylidene)-3-methyl-1,3-thiazolidine-2,4-dione(6340-89-2)
• EPA Substance Registry System: (5Z)-5-(2-chloro-6-fluorobenzylidene)-3-methyl-1,3-thiazolidine-2,4-dione(6340-89-2)

Safety Data

• Hazardous Substances Data: 6340-89-2(Hazardous Substances Data)

Usage

General Description

The chemical compound "(5Z)-5-(2-chloro-6-fluorobenzylidene)-3-methyl-1,3-thiazolidine-2,4-dione" is a thiazolidine-2,4-dione derivative with the molecular formula C11H8ClFNO2S. It is composed of a thiazolidine ring with a choloro-fluorobenzylidene substituent and a methyl group. (5Z)-5-(2-chloro-6-fluorobenzylidene)-3-methyl-1,3-thiazolidine-2,4-dione is a potential candidate for pharmaceutical research due to its thiazolidine-2,4-dione core, which is known to exhibit antidiabetic, anti-inflammatory, and anticancer activities. Its specific structure and properties make it a subject of interest for further investigation and potential pharmaceutical application.

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Relevant articles and documents

Heterogeneous SO3H@Fe3O4 magnetic nanocatalyst as an efficient and reusable medium for the synthesis of 3,3′-(arylmethylene)-bis-(4-hydroxycoumarin), bis-(indolyl)-methane, and 1,8-dioxo-octahydroxanthene derivatives

This work aimed to synthesize a new heterogeneous catalyst (SO3H@Fe3O4 magnetic nanoparticles) and the study of its catalytic behavior in synthesizing 3,3′-(arylmethylene)-bis-(4-hydroxycoumarin), bis-(indolyl)-methane, an

A Star-Shaped Triazine-Based Vitamin B5 Copper(II) Nanocatalyst for Tandem Aerobic Synthesis of Bis(indolyl)methanes

In this work, the catalytic efficiency of a novel bio-relevant triazine (TA)-based pantothenate (vitamin B5) copper(II) complex [Cu(II)-TA/B5] in the aerobic oxidation of benzyl alcohols and tandem synthesis of bis(indolyl)methanes was exploited. The star-shaped catalyst was characterized by different techniques such as FT-IR, EDX, ICP, TEM, and TGA. TEM images revealed a honeycomb structure resulting from the accumulation of nanoparticles with size ranging between 2–6 nm. The high yields and excellent selectivity were obtained for the production of various benzaldehydes and bis(indolyl)methanes under aerobic conditions. Recycling tests, spectroscopic data, and leaching experiments testified that the title heterogeneous bio-relevant catalyst preserved its activity and structural integrity during oxidation and coupling reactions. The presented catalytic systems qualify all requirements for efficient catalytic systems for applied goals.

Catalyst-free visible-light-induced condensation to synthesize bis(indolyl)methanes and biological activity evaluation of them as potent human carboxylesterase 2 inhibitors

A mild strategy for visible-light-induced synthesis of bis(indolyl)methanes was developed using aromatic aldehydes and indole as substrates. This reaction could be performed at room temperature under catalyst- and additive-free conditions to synthesize a