63400-76-0Relevant academic research and scientific papers
Organic-base-catalyzed synthesis of phthalides via highly regioselective intramolecular cyclization reaction
Kanazawa, Chikashi,Terada, Masahiro
, p. 933 - 935 (2007)
The organic-base-catalyzed 5-exo intramolecular cyclization reaction of o-alkynylbenzoic acid produces the corresponding phthalide regioselectively in good to excellent yields. The method provides a practical access to the phthalides, an important class o
Design, synthesis and biological evaluation of substituted flavones and aurones as potential anti-influenza agents
Chintakrindi, Anand S.,Gohil, Devanshi J.,Chowdhary, Abhay S.,Kanyalkar, Meena A.
, (2019/11/29)
We designed a series of substituted flavones and aurones as non-competitive H1N1 neuraminidase (NA) inhibitors and anti-influenza agents. The molecular docking studies showed that the designed flavones and aurones occupied 150-cavity and 430-cavity of H1N1-NA. We then synthesized these compounds and evaluated these for cytotoxicity, reduction in H1N1 virus yield, H1N1-NA inhibition and kinetics of inhibition. The virus yield reduction assay and H1N1-NA inhibition assay demonstrated that the compound 1f (4-methoxyflavone) had the lowest EC50 of 9.36 nM and IC50 of 8.74 μM respectively. Moreover, kinetic studies illustrated that compounds 1f and 2f had non-competitive inhibition mechanism.
Synthesis of isocoumarins: Rhenium complex-catalyzed cyclization of 2-ethynylbenzoic acids
Umeda, Rui,Yoshikawa, Shunya,Yamashita, Kouji,Nishiyama, Yutaka
, p. 2172 - 2179 (2015/12/12)
When 2-ethynylbenzoic acids were treated with a catalytic amount of a rhenium complex, such as ReCl(CO)5, 6-endo cyclization of 2-ethynylbenzoic acids proceeded with a high selectivity to give the corresponding isocoumarins in moderate to good yields.
Antimalarial activity of imidazo[2,1-a]isoindol-5-ol derivatives and related compounds
Olmo, Esther Del,Barboza, Bianca,Chiaradia, Louise D.,Moreno, Alicia,Carrero-Lérida, Juana,González-Pacanowska, Dolores,Mu?oz, Victoria,López-Pérez, José L.,Giménez, Alberto,Benito, Agustín,Martínez, Antonio R.,Ruiz-Pérez, Luis M.,San Feliciano, Arturo
experimental part, p. 5379 - 5386 (2011/12/14)
The synthesis of several series of imidazo[2,1-a]isoindol-5-ol derivatives and the results of their evaluation against Plasmodium falciparum are presented and discussed. The effects of electron-withdrawing or-donating substituents on different parts of the molecule, as well as those produced by the incorporation of an additional fused ring, were analyzed. Several compounds showed significant antimalarial activity in vitro with IC50 values as low as 60 nM and a certain efficacy in vivo by reducing parasitemia in Plasmodium berghei mouse models.
