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Usage

Uses

Used in Pharmaceutical Industry:
Gentisic acid is used as an intermediate in the synthesis of pharmaceuticals for its antioxidant and anti-inflammatory properties. It can be incorporated into formulations to treat various medical conditions that benefit from these properties.
Used in Agrochemical Industry:
Gentisic acid is used as an intermediate in the synthesis of agrochemicals, where its antioxidant and anti-inflammatory properties can contribute to the development of more effective and safer products for agricultural applications.
Used in Biomarker Research:
Gentisic acid has been investigated for its potential as a biomarker for various diseases. Its presence in biological samples can be analyzed to aid in the diagnosis, prognosis, or monitoring of certain conditions.
Used in Food and Cosmetic Industry:
Gentisic acid has been studied as a natural preservative in food and cosmetic products. Its antioxidant properties can help extend the shelf life of products and maintain their quality, while its anti-inflammatory properties may provide additional benefits for skin health and other applications.

Upstream product

• 60547-92-4 4-(benzyloxy)-5-methoxy-2-nitrobenzoic acid 
• 140647-01-4 4-hydroxy-5-methoxy-2-nitrobenzoic acid 

Relevant academic research and scientific papers

One-pot microwave-assisted selective azido reduction/tandem cyclization in condensed and solid phase with nickel boride

An efficient and inexpensive method using microwave-assisted irradiation with Ni2B for the syntheses of aromatic amines, pyrrolobenzodiazepines as well as pyrroloquinazolinones was developed. This protocol was applied in the tandem resin-cleavage, azido reduction, and cyclization of compounds 3 and 5 that afforded substituted pyrrolo[2,1-c][1,4] benzodiazepines 4 and 6 in a one-pot manner. The microwave-assisted irradiation reactions enhanced yields with very short reaction times in contrast to the conventional thermal reactions. Georg Thieme Verlag Stuttgart.

An efficient selective reduction of aromatic azides to amines employing BF3·OEt2/NaI: Synthesis of pyrrolobenzodiazepines

A selective and facile method for the reduction of aromatic azides to amines by employing borontrifluoride diethyl etherate and sodium iodide. This methodology has been applied towards the preparation of biologically important imine-containing pyrrolobenzodiazepines and their dilactams through intramolecular reductive-cyclization process. In this protocol the reagent systems are amenable for the generation of solution-phase combinatorial synthesis. Georg Thieme Verlag Stuttgart.

ORGANIC COMPOUNDS

The present invention relates to quinazolinone compounds of the formula wherein R2, R3, R5, R6 R7 and R8 are as defined in the specification and in the claims, in free form or in salt form , processes for their preparation and their use as pharmaceuticals, particularly in the treatment of disorders ameliorated by administration of TRPV1 antagonists.

A mild and facile reduction of azides to amines by N,N-dimethylhydrazine and catalytic ferric chloride

Reaction of a variety of azido compounds with N,N-dimethylhydrazine in the presence of a catalytic amount of ferric chloride hexahydrate in methanol results in excellent yields of the corresponding amino compounds. This reductive system is compatible with a wide assortment of functional groups and has also been extended towards the synthesis of pyrrolo[2,1-c][1,4]benzodiazepine antibiotics.

Synthesis of pyrrolo[2,1-c][1,4]benzodiazepines via an intramolecular aza-Wittig reaction. Synthesis of the antibiotic DC-81

A new and efficient synthesis of the pyrrolo[2,1-c][1,4]benzodiazepine ring system has been carried out using, as a key step, an intramolecular aza-Wittig reaction of the appropriately substituted N-(2-azidobenzoyl)pyrrolidine-2-carboxaldehydes. The paren