63407-32-9

Basic information

• Product Name: 2-amino-4-hydroxy-5-methoxybenzoic acid
• Synonyms: 2-amino-4-hydroxy-5-methoxybenzoic acid
• CAS NO: 63407-32-9
• Molecular Formula: C₈H₉NO₄
• Molecular Weight: 183.16136
• Mol File: 63407-32-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 169-171 °C
• Boiling Point: 408.4 °C at 760 mmHg
• Flash Point: 200.8 °C
• Appearance: /
• Density: 1.445 g/cm³
• PKA: 2.45±0.10(Predicted)
• CAS DataBase Reference: 2-amino-4-hydroxy-5-methoxybenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-4-hydroxy-5-methoxybenzoic acid(63407-32-9)
• EPA Substance Registry System: 2-amino-4-hydroxy-5-methoxybenzoic acid(63407-32-9)

Safety Data

• Hazardous Substances Data: 63407-32-9(Hazardous Substances Data)

Usage

General Description

2-amino-4-hydroxy-5-methoxybenzoic acid, also known as gentisic acid, is a chemical compound with the molecular formula C8H9NO4. It is a derivative of salicylic acid and is found in various plants, including the roots of gentian (from which it gets its name) and the fruits of the karaya tree. Gentisic acid is a white crystalline solid with a slightly sweet taste and is soluble in water. It has antioxidant and anti-inflammatory properties, making it potentially useful in the treatment of various medical conditions. It is also used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Additionally, gentisic acid has been investigated for its potential as a biomarker for various diseases and as a natural preservative in food and cosmetic products.

Upstream product

• 60547-92-4 4-(benzyloxy)-5-methoxy-2-nitrobenzoic acid 
• 140647-01-4 4-hydroxy-5-methoxy-2-nitrobenzoic acid 

Relevant articles and documents

One-pot microwave-assisted selective azido reduction/tandem cyclization in condensed and solid phase with nickel boride

An efficient and inexpensive method using microwave-assisted irradiation with Ni2B for the syntheses of aromatic amines, pyrrolobenzodiazepines as well as pyrroloquinazolinones was developed. This protocol was applied in the tandem resin-cleavage, azido reduction, and cyclization of compounds 3 and 5 that afforded substituted pyrrolo[2,1-c][1,4] benzodiazepines 4 and 6 in a one-pot manner. The microwave-assisted irradiation reactions enhanced yields with very short reaction times in contrast to the conventional thermal reactions. Georg Thieme Verlag Stuttgart.

ORGANIC COMPOUNDS

The present invention relates to quinazolinone compounds of the formula wherein R2, R3, R5, R6 R7 and R8 are as defined in the specification and in the claims, in free form or in salt form , processes for their preparation and their use as pharmaceuticals, particularly in the treatment of disorders ameliorated by administration of TRPV1 antagonists.

Synthesis of pyrrolo[2,1-c][1,4]benzodiazepines via an intramolecular aza-Wittig reaction. Synthesis of the antibiotic DC-81

A new and efficient synthesis of the pyrrolo[2,1-c][1,4]benzodiazepine ring system has been carried out using, as a key step, an intramolecular aza-Wittig reaction of the appropriately substituted N-(2-azidobenzoyl)pyrrolidine-2-carboxaldehydes. The paren