63417-81-2 Usage
Description
5-(CHLOROMETHYL)-3-(2-THIENYL)-1,2,4-OXADIAZOLE is a heterocyclic chemical compound that belongs to the class of oxadiazoles. It is characterized by the presence of a chlorine atom attached to a methyl group and a thienyl group on the oxadiazole ring. 5-(CHLOROMETHYL)-3-(2-THIENYL)-1,2,4-OXADIAZOLE has potential applications in various fields such as pharmaceuticals, agrochemicals, and material science due to its diverse biological and pharmacological activities. It is also used as a building block in the synthesis of other complex organic molecules. Its unique structural features make it an interesting target for medicinal chemistry research and drug discovery efforts.
Uses
Used in Pharmaceutical Industry:
5-(CHLOROMETHYL)-3-(2-THIENYL)-1,2,4-OXADIAZOLE is used as a pharmaceutical intermediate for the development of new drugs. Its diverse biological and pharmacological activities make it a promising candidate for the treatment of various diseases.
Used in Agrochemical Industry:
5-(CHLOROMETHYL)-3-(2-THIENYL)-1,2,4-OXADIAZOLE is used as an agrochemical intermediate for the synthesis of pesticides and other agrochemical products. Its unique structural features and potential biological activities make it a valuable component in the development of new agrochemicals.
Used in Material Science:
5-(CHLOROMETHYL)-3-(2-THIENYL)-1,2,4-OXADIAZOLE is used as a building block in the synthesis of various complex organic molecules for material science applications. Its unique structural features contribute to the development of new materials with improved properties.
Used in Medicinal Chemistry Research:
5-(CHLOROMETHYL)-3-(2-THIENYL)-1,2,4-OXADIAZOLE is used as a target compound in medicinal chemistry research and drug discovery efforts. Its diverse biological and pharmacological activities make it an interesting subject for further investigation and potential development into new therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 63417-81-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,4,1 and 7 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 63417-81:
(7*6)+(6*3)+(5*4)+(4*1)+(3*7)+(2*8)+(1*1)=122
122 % 10 = 2
So 63417-81-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H5ClN2OS/c8-4-6-9-7(10-11-6)5-2-1-3-12-5/h1-3H,4H2
63417-81-2Relevant articles and documents
Design, synthesis and biological evaluation of triaryl compounds as novel 20S proteasome inhibitors
Yang, Yajun,Wang, Ke,Wu, Bo,Yang, Ying,Lai, Fangfang,Chen, Xiaoguang,Xiao, Zhiyan
, (2020/09/02)
Thirty novel triaryl compounds were designed and synthesized based on the known proteasome inhibitor PI-1840. Most of them showed significant inhibition against the β5c subunit of human 20S proteasome, and five of them exhibited IC50 values at the sub-micromolar level, which were comparable to or even more potent than PI-1840. The most active two (1c and 1d) showed IC50 values of 0.12 and 0.18 μM against the β5c subunit, respectively, while they displayed no obvious inhibition against the β2c, β1c and β5i subunits. Molecular docking provided informative clues for the subunit selectivity. The potent and subunit selective proteasome inhibitors identified herein represent new chemical templates for further molecular optimization.
NEW COMPOUNDS
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Page 150, (2010/02/06)
The present invention relates to new compounds of formula I, (I) a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
C:Corrosive;
