634174-64-4Relevant academic research and scientific papers
Synthesis and free radical scavenging property of some quinoline derivatives
Subashini,Roopan, S. Mohana,Khan, F. Nawaz
, p. 317 - 319 (2010)
In the present work synthesis of 2-chloroquinoline-3-carbaldehydes (1a-g), 2-chloro-3-(1, 3-dioxolan-2-yl)quinolines (2a-g) and antioxidant activity using the DPPH assays is reported. The results showed that the compounds 1b, 1c, 2b, 2e, 2f possessed 84.6
Potential anti-bacterial agents: Montmorillonite clay-catalyzed synthesis of novel 2-(3,5-substituted-1H-pyrazol-1-yl)-3-substituted quinolines and their in silico molecular docking studies
Pavan, Pasupala,Subashini,Ethiraj,Nawaz Khan, Fazlur-Rahman
, p. 58011 - 58018 (2015/02/19)
A series of 2-(3,5-substituted-1H-pyrazol-1-yl)-3-substituted quinolines 5a-g, were obtained from 2-chloro-3-(1,3-dioxolan-2-yl) quinolines 2a-c and diketones 3a-c with great yields by utilizing Montmorillonite clay K-10 as a catalyst in an eco-friendly methodology. All the synthesized compounds were characterized by FTIR, 1H-NMR, 13C-NMR and HRMS spectral techniques. Antibacterial screening of the compounds revealed that some of the compounds demonstrate moderate to good results. Amongst all, compound 2c displayed a good inhibitory profile against P. aeruginosa and B. subtilis, while compound 5c exhibited remarkable activity against S. aureus, B. subtilis and P. aeruginosa with an MIC value of 25 μg mL-1. Moreover, compound 5c presented a MIC value of 50 μg mL-1 against E. coli and K. pneumoniae, which was comparable to that of the standard. In addition, compound 5f was demonstrated good viability against S. aureus and P. aeruginosa with a MIC value of 25 μg mL-1. Compounds 2c and 5f, however, showed relatively moderate inhibition against S. aureus, while the latter had a moderate activity against B. subtilis. To further demonstrate the antibacterial efficacy of 2c, 5c and 5f, molecular docking studies were done, confirming that compound 5c possesses good binding interaction with the peptide deformylase protein, with a binding energy of -8.1 kcal mol-1 - more prominent than that of standard ampicillin (-7.5 kcal mol-1) - while compounds 2c and 5f have moderate binding affinity. This journal is
Facile synthesis of 1-hydroxy-5-methoxy-benzo[f][2,7]naphthyridines
Rajeev,Rajendran
experimental part, p. 2837 - 2843 (2010/10/20)
A new route for the synthesis of 1-hydroxy-5-methoxy-benzo[f][2,7] naphthyridines has been developed from easily available precursor 2-chloro-3-formyl quinolines. The 2-methoxy-3-formyl quinolines were prepared and condensed with glycine ethyl ester hydrochloride. This resulted in the formation of an imines, which on cyclization with Dowtherm A yielded 1-hydroxy-5-methoxy-1,2-dihydrobenzo[f][2,7]naphthyridines.
Synthesis of pyrrolo[3,4-c]quinolines by 1,5-electrocyclisation of non-stabilised azomethine ylides
Nyerges, Miklós,Pintér, áron,Virányi, Andrea,Blaskó, Gábor,Toke, László
, p. 8199 - 8205 (2007/10/03)
A new route to the pyrrolo[3,4-c]quinoline ring system has been developed via the 1,5-dipolar electrocyclisation reactions of azomethine ylides derived from easily available 3-formylquinoline derivatives. The intermediacy of azomethine ylides was shown by the trapping of the proposed dipoles with N-phenylmaleimide.
