63418-55-3Relevant academic research and scientific papers
Synthesis of Some Novel Class of Bis(isoxazoline) and Bis(aziridine) Derivatives
Chakraborty, Bhaskar,Singh Chettri, Manjit,Prasad Luitel, Govinda
, p. 1611 - 1618 (2017)
Synthesis of some new bis(isoxazoline) derivatives has been described from terepthaldehyde derived bis(nitrones) using microwave irradiation via 1,3-dipolar cycloaddition reaction. Bis(isoxazoline) derivatives in turn successfully converted into new bis(a
Microwave assisted synthesis of some novel class of bisisoxazoline derivatives and their further applications
Chakraborty, Bhaskar,Luitel, Govinda Prasad,Chhetri, Manjit Singh
, p. 1259 - 1266 (2017/04/28)
Synthesis of some new bisisoxazoline derivatives have been described from terepthaldehyde derived hisnitrones using microwave irradiation via 1,3-dipolar cycloaddition reaction. Bisisoxazoline derivatives have been in tum successfully converted into new b
Simultaneous double 1,3-dipolar cycloaddition reactions involving bisnitrones or bisdipolarophiles.1H NMR investigation of the conformational preferences of N-methyl- And N-phenylisoxazolidines
Heancy, Frances
, p. 373 - 378 (2007/10/03)
Bisnitrones la and lb reacted with N-methylmaleimide giving bisisoxazolidines. Diastereospecific reaction of the phenyl substituted dipole la gave 3a whilst the N-methyl dipole lb furnished diastereomeric adducts 3b, 4 and 7 classified as trans,trans, 3b, cis,cis, 4 and cis,trans adducts 7 (major) according to the relative orientation of the 3-H and 4-H protons on each isoxazolidine ring. Similar behaviour was observed in reaction of mono dipoles N-benzylideneaniline N-oxide and N-benzylidenemethylamine N-oxide with phenylenedimaleimide 2. The N-phenyl dipole reacted highly selectively furnishing the trans,trans adduct 8a whilst the N-methyl dipole again gave trans,trans 8b, cis,cis 10 and cis,trans adducts 9 (major). Some of the N-methyl substituted isoxazolidines (3b, 7, 8b, 9b) displayed a number of very broad signals in their rt 1H NMR spectra which sharpened (and duplicated) on cooling. By analogy to the corresponding 1H NMR data of the "hemi-adducts" 5 and 6, and with reference to crystal structure data for 5c [Fig. 1], it was shown that for this group of adducts the 3-H and 4-H protons are trans orientated. The isoxazolidine ring in these adducts equilibrates between the o- and i-conformations [Fig. 2] and at -40°C each conformer can be clearly identified in the 1H NMR spectrum. No line broadening was observed in the 1H NMR spectra of any of the N-phenyl substituted adducts. The conformational freedom of the adducts is thus dictated by the size of the N-isoxazolidine substituent and the relative orientation of the 3-H and 4-H protons. All new cycloadducts reported, 3-10, are prepared as racemic mixtures and stereochemical information portrayed in the drawings implies relative and not absolute relations.
