63419-72-7 Usage
Description
Cyanogen-15N Bromide, a chemical compound with the formula BrCN, is an isotope-labeled derivative of cyanogen bromide. It is characterized by the presence of the nitrogen-15 isotope, which distinguishes it from its non-labeled counterpart. CYANOGEN-15N BROMIDE is primarily used as a synthetic intermediate in the production of various biologically active molecules.
Uses
Used in Pharmaceutical Industry:
Cyanogen-15N Bromide is used as an intermediate in the synthesis of 5-Azacytidine-15N4 (A796002), a labeled version of the potent growth inhibitor and cytotoxic agent, Azacytidine (A796000). This labeled compound serves as a valuable tool in research and development, allowing for the study of the compound's interactions and effects at the molecular level.
As a demethylating agent, 5-Azacytidine-15N4 inhibits DNA methyltransferase, a key enzyme involved in the regulation of gene expression. This inhibition can lead to the reactivation of silenced genes, making it a promising candidate for the treatment of various cancers and other diseases associated with abnormal gene silencing.
In addition to its role in the synthesis of 5-Azacytidine-15N4, Cyanogen-15N Bromide may also be utilized in the development of other labeled compounds with potential applications in the pharmaceutical industry. These applications could include the study of drug metabolism, the development of targeted therapies, and the investigation of novel drug delivery systems.
Check Digit Verification of cas no
The CAS Registry Mumber 63419-72-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,4,1 and 9 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 63419-72:
(7*6)+(6*3)+(5*4)+(4*1)+(3*9)+(2*7)+(1*2)=127
127 % 10 = 7
So 63419-72-7 is a valid CAS Registry Number.
63419-72-7Relevant articles and documents
Synthesis of multiply labelled ribonucleosides for sequence-specific labelling of oligo-RNA
Milecki, Jan,Foeldesi, Andras,Fischer, Artur,Adamiak, Ryszard W.,Chattopadhyaya, Jyoti
, p. 763 - 783 (2007/10/03)
The synthesis of ribonucleotide blocks multiply labelled with 2H, 13C and 15N for solid support synthesis of sequence specifically labelled RNA is described. Labels were introduced in the ribose ring (13C), C5 position of pyrimidine nucleobases (2H) and exocyclic amino groups (15N) and serve as multiple probes for studying the various physicochemical consequences of physiologically important RNA folding by high-resolution multi-nuclear NMR spectroscopy.
