634199-51-2Relevant academic research and scientific papers
Pyrimidine derivatives as ghrelin receptor modulators
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Page/Page column 28, (2010/02/11)
The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by ghrelin including anorexia, cancer cachexia, eating disorders, age-related decline in body composition, weight gain, obesity, and diabetes mellitus.
An expeditious synthesis of 6-alkyl-5-(4′ -amino-phenyl)-pyrimidine-2,4-diamines
Holsworth, Daniel D.,Stier, Michael,Edmunds, Jeremy J.,He, Wei,Place, Samuel,Maiti, Samarendra
, p. 3467 - 3475 (2007/10/03)
A rapid synthesis of a series of 6-alkyl substituted-5-(4′ -amino-phenyl)-pyrimidine-2,4-diamines is described. These analogs were produced in good yields on moderate scale (ca. 8 g) without chromatography. Furthermore, the methodology described herein al
