6342-10-5Relevant academic research and scientific papers
Gum arabic-OPO3H2as a new natural-based green catalyst for the one-pot pseudo-four-component synthesis of naphtho[1,2-: E] [1,3]oxazines
Bamoniri, Abdolahamid,Fatemeh Mirjalili, Bi Bi,Hosseinikhah, Sahar Saadat,Salehi, Naeimeh
, p. 40508 - 40513 (2020/11/18)
Gum arabic-OPO3H2 (GA-OPO3H2) as a unique natural-based green catalyst was synthesized by the reaction of phosphorus pentoxide with gum arabic. The structure and properties of the catalyst were studied via several analysis methods such as FT-IR, MAPPING, EDS, SEM, XRD, and TGA. The efficiency of the above-mentioned catalyst was investigated for the synthesis of naphtho-1,3-oxazines via a pseudo-four-component reaction of primary amines, formaldehyde, and 2-naphthol under the solvent-free grinding condition at room temperature using an electrical mortar-heater. The obtained results indicated that GA-OPO3H2 is a highly efficient green catalyst for the synthesis of naphtho[1,2-e][1,3]oxazines with high yields, simple workup, and benign reaction condition.
Nano-Fe3O4?walnut shell/Cu(ii) as a highly effective environmentally friendly catalyst for the one-potpseudothree-component synthesis of 1,3-oxazine derivatives under solvent-free conditions
Fatemeh Mirjalili, Bi Bi,Tafti, Arefeh Dehghani
, p. 31874 - 31880 (2020/09/21)
Fe3O4?walnut shell/Cu(ii) as an eco-friendly bio-based magnetic nano-catalyst was prepared by adding CuCl2to Fe3O4?walnut shell in alkaline medium. A series of 2-aryl/alkyl-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazines were synthesized by the one-potpseudothree-component reaction of β-naphthol, formaldehyde and various amines using nano-Fe3O4?walnut shell/Cu(ii) at 60 °C under solvent-free conditions. The catalyst was removed from the reaction mixture by an external magnet and was reusable several times without any considerable loss of its activity. This protocol has several advantages such as excellent yields, short reaction times, clean and convenient procedure, easy work-up and use of an eco-friendly catalyst.
β-naphthol in glycerol: A versatile pair for efficient and convenient synthesis of aminonaphthols, naphtho-1,3-oxazines, and benzoxanthenes
Ganesan, Subramaniapillai Selva,Rajendran, Narendran,Sundarakumar, Sankahr Ilathur,Ganesan, Asaithampi,Pemiah, Brindha
, p. 1564 - 1568 (2013/06/27)
Three-component Betti reaction was carried out in the environmentally benign, inexpensive, non-toxic solvent glycerol. Even in the absence of a catalyst, the reaction went completion with an unprecedented high rate and the expected Betti bases were obtained in up to 91% yield. The reaction works well for representative cyclic, acyclic, aliphatic, and aromatic amines and aldehydes. A benzoxanthene was also prepared in 93% yield following the same methodology with 20 mol% methanesulfonic acid catalyst. Georg Thieme Verlag Stuttgart New York.
Ultrasound-assisted one-pot synthesis of 1,3-oxazine derivatives catalysed by BF3-SiO2 under neat conditions
Reddy, Mudumala Veeranarayana,Lim, Kwon Taek,Kim, Jong Tae,Jeong, Yeon Tae
experimental part, p. 398 - 401 (2012/09/21)
An efficient and environment-friendly method for the synthesis of 1,3-oxazine derivatives has been developed using the ultrasound-mediated condensation of 2-naphthol with formaldehyde and primary amines under solvent-free condition at room temperature in
An eco-friendly synthesis and antimicrobial activities of dihydro-2H-benzo- and naphtho-1,3-oxazine derivatives
Mathew, Bijoy P.,Kumar, Awanit,Sharma, Satyasheel,Shukla,Nath, Mahendra
experimental part, p. 1502 - 1507 (2010/06/14)
A series of 3,4-dihydro-2H-benzo[e]-, 2,3-dihydro-1H-naphtho[1,2-e]-, 3,4-dihydro-2H-naphtho[2,1-e][1,3]oxazine and 1,2-bis(3,4-dihydrobenzo[e][1,3]oxazin-3(4H)-yl)ethane derivatives was obtained through an eco-friendly Mannich type condensation-cyclization reaction of phenols or naphthols with formaldehyde and primary amines in water at ambient temperature. Preliminary in vitro antimicrobial activity of the synthesized compounds was assessed against six pathogenic fungi, two Gram-negative and two Gram-positive bacteria. Some of the screened compounds have shown significant in vitro antimicrobial effect. Cytotoxic activities of the lead compounds (2m, 2n, 3c and 3d) against mouse fibroblast cell line (L929) were determined by MTT method. The assay results revealed that these molecules offered remarkable viability (>90%) of L929 cells at concentration of 25?μg/mL.
One-pot three-component synthesis of dihydrobenzo- and naphtho[e]-1,3- oxazines in water
Mathew, Bijoy P.,Nath, Mahendra
experimental part, p. 1003 - 1006 (2009/12/06)
(Chemical Equation Presented) A simple, green and efficient method has been developed for the synthesis of biologically and materially important dihydrobenzo/naphtho[e]-1,3-oxazines in good to excellent yields through a Mannich-type condensation cyclizati
