63429-99-2

Usage

Uses

Used in Organic Synthesis:
5-Chloro-2-methoxyphenyl isothiocyanate is used as a reagent for the introduction of the isothiocyanate functional group onto other molecules. This allows for the production of a variety of sulfur-containing organic compounds, which are valuable in the development of new materials and pharmaceuticals.
Used in Pharmaceutical Synthesis:
As a building block, 5-chloro-2-methoxyphenyl isothiocyanate is utilized in the synthesis of pharmaceuticals. Its unique structure contributes to the creation of new drug candidates with potential therapeutic properties.
Used in Agrochemical Synthesis:
5-CHLORO-2-METHOXYPHENYL ISOTHIOCYANATE also serves as a key intermediate in the production of agrochemicals, specifically pesticides and fungicides, due to its potent biocidal properties.
Used in Industrial Applications:
5-Chloro-2-methoxyphenyl isothiocyanate is applied in various industrial processes, where its chemical properties are harnessed to improve or create new products, particularly those that require sulfur-containing compounds.
It is crucial to handle 5-chloro-2-methoxyphenyl isothiocyanate with care due to its potential hazards if not used properly, emphasizing the need for safety measures in its applications across different industries.

InChI:InChI=1/C8H6ClNOS/c1-11-8-3-2-6(9)4-7(8)10-5-12/h2-4H,1H3

Upstream product

• 463-71-8 thiophosgene 
• 95-03-4 5-chloro-2-methoxyaniline 

Downstream Products

• 63980-69-8 (2-methoxy-5-chlorophenyl)-2-thiourea 
• 137-52-0 N-[2-methoxy-5-chlorophenyl]-3-hydroxy-2-naphthalene carboxamide 
• 127142-55-6 C₁₆H₁₇ClN₆OS₂ 
• 187866-52-0 2-[3-(5-chloro-2-methoxyphenyl)-thioureido]-acetamide 
• 492450-76-7 3-[3-(5-chloro-2-methoxy-phenyl)-thioureido]-2,2-dimethyl-propionic acid methyl ester 
• 869278-94-4 O-isopropyl 5-chloro-2-methoxyphenylthiocarbamate 
• 1065641-49-7 methyl N-5-chloro-2-methoxyphenyl-N'-cyanocarbamimidothioate 
• 1152595-02-2 O-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl] 5-chloro-2-methoxyphenylthiocarbamate 
• 1039924-36-1 4-(5-chloro-2-methoxyphenyl)-3-thiosemicarbazide 

Relevant academic research and scientific papers

USP8 inhibitor, preparation method and applications thereof

The invention discloses a USP8 inhibitor, a preparation method and applications thereof, belongs to the field of medicinal chemistry, and particularly relates to a class of USP8 inhibitors (I) containing substituted thiourea or substituted guanidine derivatives, and a preparation method thereof. According to the invention, the results of biological experiments prove that the compound has good USP8inhibitory activity and cell activity and can be used for treating diseases such as malignant tumors and the like.

Discovery of novel USP8 inhibitors via Ubiquitin-Rho-110 fluorometric assay based high throughput screening

USP8, one member of deubiquitinating enzymes (DUBs) families, maintains the ubiquitination level of EGFR and regulates the downstream signaling pathways. The deregulation of USP8 has been implicated in many human diseases, especially in cancer. Therefore, USP8 has been identified as a promising target for drug design. Herein, via high throughput screening based on Ubiquitin-rhodamine-110 (Ubiquitin-Rho-110) fluorometric activity assay, we discovered a novel inhibitor DC-U43. By structure optimization, DC-U43-10 reached a half-maximal inhibitory concentration (IC50) value of 2.6 ± 1.1 μM and exhibited 10-fold selectivity against USP7. The binding between DC-U43-10 and USP8 was validated by surface plasmon resonance (SPR) assay with a KD value of 10.5 ± 3.7 μM. It also inhibited the colony formation of H1975 cells. Hence, DC-U43-10 represents a kind of USP8 inhibitors with novel scaffold and has broad prospects for being a probe for USP8-related academic and clinical research.