63430-93-3

Usage

General Description

1-Propanol, 2-(phenylamino)-, (R)- is a chiral alcohol compound that has a molecular formula of C9H13NO. Also known as R-(-)-1-Phenyl-2-propanol, it is a colorless liquid with a faint odor. This chemical is synthesized by the reduction of acetophenone with a chiral reducing agent. It is commonly used as a chiral auxiliary in asymmetric syntheses and as a resolving agent for the separation of racemic mixtures. Additionally, it has applications in the pharmaceutical and fragrance industries as a key intermediate in the production of various compounds. However, it is important to handle this chemical with care, as it can cause irritation to the skin, eyes, and respiratory system.

Upstream product

• 709-80-8 methyl N-(2, 6-dimethylphenyl)alaninate 
• 62-53-3 aniline 
• 93865-37-3 1-(N-phenylalanyl)piperidine 

Relevant academic research and scientific papers

Highly Enantioselective Hydrogenation of Amides via Dynamic Kinetic Resolution Under Low Pressure and Room Temperature

High-throughput screening and lab-scale optimization were combined to develop the catalytic system trans-RuCl2((S,S)-skewphos)((R,R)-dpen), 2-PrONa, and 2-PrOH. This system hydrogenates functionalized α-phenoxy and related amides at room temperature under 4 atm H2 pressure to give chiral alcohols with up to 99% yield and in greater than 99% enantiomeric excess via dynamic kinetic resolution.

A homogeneous catalyst for reduction of optically active esters to the corresponding chiral alcohols without loss of optical purities

A ruthenium complex was found to catalyze the hydrogen reduction of esters under mild and neutral conditions. A variety of optically active esters can be reduced to the corresponding alcohols in excellent yield without loss of their optical purity or causing undesirable side reactions. Hydrogen reduction needs such simple operations - reaction, concentration, and purification - that the violent quench step and extraction step, which accompany conventional sodium borohydride or lithium aluminum hydride reduction, can be omitted.