63432-41-7Relevant articles and documents
Two new biologically active triterpenoidal saponins acylated with salicylic acid from Albizia adianthifolia
Haddad, Mohamed,Miyamoto, Tomofumi,Laurens, Veronique,Lacaille-Dubois, Marie-Aleth
, p. 372 - 377 (2003)
Two new oleanane-type triterpene saponins, adianthifoliosides A (1) and B (2), were isolated from a 95% ethanolic extract of roots of Albizia adianthifolia. Their structures were elucidated mainly by using a combination of 600 MHz 1D and 2D NMR techniques (COSY, NOESY, TOCSY, HSQC, and HMBC) and by FABMS and HRESIMS. Compounds 1 and 2 were characterized as glycosides of acacic acid acylated by an o-hydroxybenzoyl unit. The crude saponin mixture (CSM), compounds 1 and 2 together with 3 and 4 (prosapogenins obtained from the mild alkaline hydrolysate of the CSM), were evaluated for immunomodulatory activity on the Jurkat T cell line and for hemolytic property against sheep erythrocytes. Compound 2 and, to a lesser extent, 1 and 3 were found to exhibit a dose-dependent immunomodulatory effect in the concentration range 10-2-10 μM, whereas 4 showed a lymphoproliferative activity in the same concentration range. Among the compounds tested, only 1 and 2 were found to be hemolytic.
TRAGOPOGONOSIDES A-I, OLEANANE SAPONINS FROM TRAGOPOGON PRATENSIS
Miyase, Toshio,Kohsaka, Hiromi,Ueno, Akira
, p. 2087 - 2091 (2007/10/02)
Nine new triterpenic saponins, named tragopogonosides A-I, were isolated from the whole plants of Tragopogon pratensis, together with five known triterpenic glycosides.The structures of these saponins were determined on the basis of spectral and chemical evidence. Key Word Index - Tragopogon pratensis; Compositae; triterpene saponin;tragopogonoside; echinocystic acid; acacic acid lactone; tormentic acid.
