63435-87-0Relevant academic research and scientific papers
Pharmacochemistry of the furoxan ring: Recent developments
Calvino,Di Stilo,Fruttero,Gasco,Sorba,Gasco
, p. 321 - 334 (2007/10/02)
In the present work recent results obtained in the pharmacochemistry of the furoxan system are reported. In particular, after a brief description of the salient points of the furoxan chemistry, the synthesis and the properties of a series of Nifedipine and Prazosin analogues, containing this heterocyclic system, are described. Since we observed that a few furoxan derivatives are able to elicit both a dose-dependent rise in platelet cGMP levels and to promote a dose-dependent inhibition of AA-induced [Ca++] rise, and that many substituted furoxans show potent vasodilating and antiaggregatory activity, the possibility of using the furoxan system as a lead in the design of new vasodilators is also discussed.
4-Methyl-3-(arylsulfonyl)furoxans: A New Class of Potent Inhibitors of Platelet Aggregation
Calvino, R.,Fruttero, R.,Ghigo, D.,Bosia, A.,Pescarmona, G. P.,Gasco, A.
, p. 3296 - 3300 (2007/10/02)
A series of 4-methyl-3-(arylthio)furoxans were synthesized by oxidation of 1-(arylthio)-2-methylglyoxymes with dinitrogen tetroxide.Reduction with trimethyl phosphite of the furoxan derivatives afforded the corresponding furazans, while oxidation with an
