63440-60-8

Usage

Uses

Used in Pharmaceutical Industry:
2-oxo-2-o-tolylacetaldehyde hydrate is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its versatility in organic synthesis allows for the creation of a wide range of medicinal agents.
Used in Agrochemical Industry:
In the agrochemical industry, 2-oxo-2-o-tolylacetaldehyde hydrate serves as a key intermediate in the production of various agrochemicals, contributing to the development of effective pesticides and other agricultural products.
Used in Dye Industry:
2-oxo-2-o-tolylacetaldehyde hydrate is utilized as a building block in the synthesis of organic dyes, providing a foundation for the creation of diverse colorants used in various applications.
Used in Organic Chemistry Research:
As a versatile chemical intermediate, 2-oxo-2-o-tolylacetaldehyde hydrate is used in organic chemistry research to explore new synthetic pathways and develop complex organic molecules for a range of applications.

InChI:InChI=1/C9H8O2/c1-7-4-2-3-5-8(7)9(11)6-10/h2-6H,1H3

Upstream product

• 609-40-5 2-nitrothiophene 
• 95-13-6 1-indene 

Downstream Products

• 122479-26-9 6-Chloro-2-o-tolyl-imidazo[1,2-b]pyridazin-3-ol 
• 72111-55-8 5-o-tolyl-pyrazine-2,3-dicarbonitrile 
• 1275575-58-0 1-(2-methylbenzoyl)-9H-β-carboline-3-carboxylic acid 
• 6912-99-8 (9H-β-carbolin-1-yl)-o-tolyl-methanone 
• 1616777-80-0 2-hydroxy-3-(2-phenyloxazol-5-yl)-1-(o-tolyl)propan-1-one 

Relevant academic research and scientific papers

Photochemical reactivity of aromatic and heteroaromatic nitroderivatives in the presence of arylalkenes

The irradiation of styrene in the presence of nitroarenes in acetonitrile gives the corresponding nitrones in high yields. However, when 4-methyl-5-ethenylthiazole is used as arylalkene the starting material is converted to a pyrrole analogous of thianthrene. On the contrary, when 1,1-diphenylethylene is used, the main product observed is benzophenone. Nitrones are obtained only as minor products. An unusual coupling product, where a substitution reaction has occurred on the carbon bearing the nitro group, is also obtained. trans-Stilbene is unreactive under the same photochemical conditions, and it gives in low yields only benzaldehyde. Finally, indene gives, when aromatic nitro derivatives are used, only oxidation products, while, when heteroaromatic nitro derivatives are used, only substitution products on the nitro group are observed. The above described reactivity can be explained by using the results of AM1 semiempirical calculations on the frontier orbitals of the reagents. Both the nature of the LSOMO of the nitroarenes and the dipole moments of the reagents can account for the observed reactivity. The nitrone obtained in the photochemical reaction between styrene and nitrobenzene is used as starting material in a 1,3-dipolar cycloaddition reaction with styrene.