63446-38-8Relevant academic research and scientific papers
SUBSTITUTED 6-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF
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Page/Page column 194-195, (2018/04/27)
The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.
HETEROTRICYCLIC COMPOUNDS AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
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Page/Page column 31, (2010/08/04)
The present invention relates to novel compounds of Formula (I), wherein wherein X1, X2, Y, Z1, Z2, Z3, M and (A)m are defined as in Formula (I); invention compounds are modulators of metab
Synthesis and structural study of tetrahydroindazolones
Claramunt, Rosa M.,López, Concepción,Pérez-Medina, Carlos,Pinilla, Elena,Torres, M. Rosario,Elguero, José
, p. 11704 - 11713 (2007/10/03)
Multinuclear magnetic resonance spectroscopy allowed us to characterize four 1(2),5,6,7-tetrahydro-4H-indazol-4-one derivatives (1-4) and establish the most stable tautomer in each case. The crystal structure of 6,6-dimethyl-1(2),5,6,7-tetrahydro-4H-indaz
SYNTHESIS OF ANGULAR BENZODIPYRAZOLES AND RELATED SYSTEMS
Peet, Norton P.,LeTourneau, Michael E.
, p. 41 - 72 (2007/10/02)
A series of benzodipyrazoles was prepared from cyclohexane-1,3-dione.Several related systems with different central rings were also prepared.In addition, benzodipyrazoles were synthesized from 1,4-cyclohexanedione monoethylene
Dipyrazoles and their use as bronchodilators
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, (2008/06/13)
A group of variously methyl-substituted[1,2-c:3,4-c']dipyrazoles, cyclohepta[1,2-c:3,4-c']dipyrazoles, and cyclopenta[1,2-c:3,4-c']dipyrazoles useful as bronchodilators are described herein. The compounds are prepared by reacting a 1,3-diketone with hydra
Cycloalkane[1,2-c:4,3-c']dipyrazoles and their use as bronchodilators
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, (2008/06/13)
The present invention is directed to a group of methylated tetrahydro cyclohepta[1,2-c:4,3-c']dipyrazoles and benzo[1,2-c:4,3-c']dipyrazoles useful as bronchodilators. The compounds are prepared by the reaction of an appropriate hydrazine with an appropri
