634465-43-3

Usage

Chemical class

piperidine

Organic compound

contains a piperidine ring

Protecting group

BOC (tert-butyloxycarbonyl)

Functional groups

cyano group, trifluoromethylphenyl group

Applications

organic synthesis, pharmaceutical products, important chemicals

Role of BOC group

protects amine group from unwanted reactions, allows selective manipulations

Influence of cyano and trifluoromethyl groups

unique chemical properties, reactivity, biological activity

Value

versatile compound in organic chemistry

Upstream product

• 118753-70-1 N-(tert-butyloxycarbonyl)bis(2-chloroethyl)amine 
• 2338-76-3 3-trifluoromethylphenylacetonitrile 

Downstream Products

• 852937-43-0 tert-butyl 4-(aminomethyl)-4-[3-(trifluoromethyl)phenyl]piperidine-1-carboxylate 
• 250290-09-6 4-[3-(Trifluoromethyl)phenyl]-4-piperidinecarbonitrile hydrochloride 

Relevant academic research and scientific papers

4-PHENYLPIPERAZIN-1-YL)ACYLPIPERIDINE DERIVATIVES, PREPARATION THEREOF AND APPLICATION OF SAME IN THERAPEUTICS

The invention relates to substituted (4-phenylpiperazin-1-yl)acylpiperidine derivatives of formula (I) in the form of a base or an addition salt with an acid, and also in the form of a hydrate or solvate, and their preparation process and therapeutic application.

Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof

The invention relates to substituted 1-piperazinylacylpiperidine derivatives of general formula (I) in which: n is 1 or 2; p is 1 or 2; R1 represents a halogen atom; a trifluoromethyl radical; a (C1-C4)alkyl; a (C1-C4)alkoxy; a trifluoromethoxy radical; R2 represents a hydrogen atom or a halogen atom; R3 represents a hydrogen atom; a group —OR5; a group —CH2OR5; a group —NR6R7; a group —NR8COR9; a group —NR8CONR10R11; a group —CH2NR12R13; a group —CH2NR8CONR14R15; a (C1-C4)alkoxycarbonyl; a group —CONR16R17; or else R3 constitutes a double bond between the carbon atom to which it is attached and the adjacent carbon atom of the piperidine ring; R4 represents an aromatic group selected from: the said aromatic groups being unsubstituted or being mono- or disubstituted by a substituent selected independently from a halogen atom; a (C1-C4)alkyl; a (C1-C4)alkoxy; a trifluoromethyl radical; Preparation process and therapeutic application.