634469-41-3

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-2-piperazin-1-yl-pyrimidine hydrochloride is used as a chemical intermediate for the synthesis of potential antipsychotic and antidepressant drugs, leveraging its ability to modulate neurotransmission related to serotonin and dopamine.
Used in Neurological and Psychiatric Drug Development:
In the field of neurological and psychiatric drug development, 4-Chloro-2-piperazin-1-yl-pyrimidine hydrochloride is utilized as a key component in the creation of novel therapeutics targeting mental health conditions, due to its unique structure and pharmacological properties that allow for modulation of critical neurotransmitters.

InChI:InChI=1/C8H11ClN4.ClH/c9-7-1-2-11-8(12-7)13-5-3-10-4-6-13;/h1-2,10H,3-6H2;1H

Upstream product

• 479691-42-4 tert-butyl 4-(4-chloropyrimidin-2-yl)piperazine- 1-carboxylate 

Relevant academic research and scientific papers

HETEROCYCLYL COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE

The present invention relates to compounds of formula (I), wherein R1 to R3, A and Q are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

THERAPEUTIC COMPOUNDS AND COMPOSITIONS

Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.

Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof

The invention relates to substituted 1-piperazinylacylpiperidine derivatives of general formula (I) in which: n is 1 or 2; p is 1 or 2; R1 represents a halogen atom; a trifluoromethyl radical; a (C1-C4)alkyl; a (C1-C4)alkoxy; a trifluoromethoxy radical; R2 represents a hydrogen atom or a halogen atom; R3 represents a hydrogen atom; a group —OR5; a group —CH2OR5; a group —NR6R7; a group —NR8COR9; a group —NR8CONR10R11; a group —CH2NR12R13; a group —CH2NR8CONR14R15; a (C1-C4)alkoxycarbonyl; a group —CONR16R17; or else R3 constitutes a double bond between the carbon atom to which it is attached and the adjacent carbon atom of the piperidine ring; R4 represents an aromatic group selected from: the said aromatic groups being unsubstituted or being mono- or disubstituted by a substituent selected independently from a halogen atom; a (C1-C4)alkyl; a (C1-C4)alkoxy; a trifluoromethyl radical; Preparation process and therapeutic application.