634585-58-3Relevant academic research and scientific papers
Chelate vs monodentate amine effects. Direct comparison of bis(acetato)amminedichloro(cyclohexylamine)platinum(IV) (JM216) with its N-cyclohexyl-1,3-propanediamine analogue
Lee, Young-A.,Kang, Shin Won,Park, Jong Yul,Jung, Ok-Sang
, p. 129 - 133 (2003)
In order to investigate the chelate effects on physicochemical properties including antitumor activity, new cis,trans,cis,[PtIVCl 2L2(chpda)] complexes (L = OH, OCOCH3; chpda = N-cyclohexyl-1,3-propanediamine) have been synthesized and characterized. The crystal structure of cis,trans,cis-[ptIVCl2(OCOCH 3)2(chpda)] (monoclinic P21/a, a = 7.947(1), b = 22.753(11), and c = 10.581(3) ?, β = 110.70(2)°, V = 1790(1) ?3, Z = 4, R = 0.0534) shows that the platinum(IV) center adopts a typical octahedral arrangement with two acetate groups in a trans position. The pattern and strength of the intramolecular hydrogen bonds are delicately different from those of JM216. Both in vitro and in vivo (oral) cytotoxicities on mouse leukemia L1210 cell line indicate that the activity of chpda chelate analogue is not better than that of the corresponding compound with two monodentate amines (JM216).
