634585-80-1Relevant academic research and scientific papers
The synthesis of some chiral 2-aminoalkyloxazole-4-carboxylates from isoxazol-5(2H)-ones
Cox, Matthew,Prager, Rolf H.,Svensson, Carina E.
, p. 887 - 896 (2007/10/03)
Ethyl 4-methyl-5-oxo-2,5-dihydroisoxazole-3-carboxylate can be N-acylated by a number of natural and synthetic phthalimidylamino acids in the presence of carbodiimides. The N-acyiated products form the corresponding oxazoles smoothly when irradiated at 300 nm in acetone. Removal of the phthalimido protecting group then gives 2-aminoalkyloxazole-4-carboxylate esters in good overall yields, and without significant racemization at any step.
