634587-40-9

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 634587-38-5 (2S,3R,4R)-2-benzyloxycarbonylamino-1,3,4-octadecanetriol 
• 554-62-1 D-ribo-phytosphingosine 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 1607008-37-6 C₅₈H₈₀N₂O₁₀ 
• 634587-47-6 C₃₆H₅₂N₂O₆S₂ 
• 634587-44-3 (2S,3S,4R)-2-benzyloxycarbonylamino-3,4-di-O-isopropy-lidene-1,3,4-octadecanetriol 
• 799267-95-1 [(S)-1-((4S,5R)-2,2-Dimethyl-5-tetradecyl-[1,3]dioxolan-4-yl)-allyl]-carbamic acid benzyl ester 
• 634587-42-1 (2S,3R,4R)-1-O-tert-butyldimethysilyl-2-benzyloxycarbonylamino-3,4-di-O-isopropylidene-1,3,4-octadecanetriol 

Relevant academic research and scientific papers

Method of preparation of alpha galactosyl ceramides compounds

The present invention relates to a method of preparation of α-galactosyl ceramides compounds of formula (I): comprising a step a) of glycosylation of a compound of formula (II): with a compound of formula (III):

METHOD OF PREPARATION OF α-GALACTOSYL CERAMIDES COMPOUNDS

The present invention relates to a method of preparation of α-galactosyl ceramides compounds of formula (I) comprising a step a) of glycosylation of a compound of formula (II) with a compound of formula (III).

Novel synthetic C-glycolipids, their synthesis and use to treat infections, cancer and autoimmune diseases

The invention is directed to novel compounds of formulae (I), (II) and (III): wherein X is O or NH; R3 is OH or a monosaccharide and R4 is hydrogen, or R3 is hydrogen and R4 is OH or a monosaccharide; R5 is hydrogen or a monosaccharide; and pharmaceutically acceptable salts or esters thereof. The invention is also directed to the use of the compounds both directly and as immune adjuvants for treating cancer, infectious diseases and autoimmune diseases. The invention is also directed to syntheses of the intermediates which can be used to make these novel compounds.

Efficient synthesis of α-C-galactosyl ceramide immunostimulants: Use of ethylene-promoted olefin cross-metathesis

(Chemical Equation Presented) Olefin cross-metathesis has been used to prepare α-C-galactosylceramide derivatives. The metathesis process merged vinyl and propenyl glycosides with vinyl derivatives of phytosphingosine. The use of ethylene enhanced the yie

SYNTHETIC C-GLYCOLIPID AND ITS USE FOR TREATING CANCER INFECTIOUS DISEASES AND AUTOIMMUNE DISEASES

The invention is directed to compounds of formula (I) wherein X is O, OR NH; R' is a hydrocarbon chain; R and are hydrogen, OH or a monosaccharide; R is hydrogen or a monosaccharide; Q' is optionally present and may be a C1-10 hydrocarbon; X' i