63459-12-1

Upstream product

• 86953-81-3 tert-butyl 2-hydroxypiperidine-1-carboxylate 
• 1229358-34-2 C₁₃H₂₃NO₃ 
• 24424-99-5 di-tert-butyl dicarbonate 
• 4396-01-4 isopelletierine 
• 505-18-0 2,3,4,5-tetrahydropyridine 
• 110-89-4 piperidine 
• 75844-69-8 t-butyl piperidinecarboxylate 
• 86953-87-9 3--2,4-pentanedione 

Downstream Products

• 1248344-20-8 (E)-tert-butyl 2-(4-(2-bromo-4,5-dimethoxyphenyl)-2-oxobut-3-enyl)piperidine-1-carboxylate 
• 86954-00-9 1-Oxo-2-methyleneoctahydroindolizine 

Relevant academic research and scientific papers

Deoxidized halofuginone compound and preparation method and application thereof

The invention provides a deoxidized halofuginone compound. A structural formula of the deoxidized halofuginone compound is as shown in the specification, wherein R1 refers to a halogen radical or hydrogen; R2 refers to hydrogen, a halogen radical, C1-C3 alkyl, C1-C3 alkoxy or trifluoromethyl; R3 refers to hydrogen, a halogen radical, C1-C3 alkyl, C1-C3 alkoxy or trifluoromethyl; X1 or X2 refers tonitrogen or carbon; Y refers to hydrogen, hydroxyl or carbonyl. The synthetic deoxidized halofuginone compound with piperidine as a raw material has advantages of cheapness and easiness in acquisition of the raw material, simplicity and easiness in operation of a synthesis method, high yield and product stability. The deoxidized halofuginone compound has great inhibiting effects on Gram positive(Gram) and Gram negative (Gram) and has a promising application prospect in treatment of human and poultry bacterial infection.

Seebach's conjunctive reagent enables double cyclizations

(Figure presented) When ketones flanked on both sides by nucleophilic atoms react with Seebach's nitropropenyl pivaloate reagent, direct couplings take place to give two new ring systems and three bonds. Cis-ring fusions are observed in unions leading to 5,5-, 5,6-, and 6,6-bicycles. Densely functionalized and rigid frameworks may be rapidly formed by the chemistry described herein.

Total synthesis of (±)-Vertine with Z-selective RCM as a key step

A concise total synthesis of the strained pentacyclic alkaloid (±)-Vertine has been achieved in eleven steps with the key steps being pelletierine condensation, Suzuki-Miyaura coupling, and ring-closing metathesis.

Palladium-Catalyzed Carbonylation. A New Synthesis of α-Methylene γ-, δ-, and ε-Lactams and -Lactones Including Bicyclic Lactams of Pyrrolizidine and Indolizidine Skeletons

The insertion of carbon monoxide into vinyl halides bearing the secondary amine or alcohol with a catalytic amount of Pd(OAc)2 and PPh3 was realized to give five-, six-, and seven-membered lactams and lactones carrying α-methylene groups in fairly good yields.Bicyclic heterocycles, pyrrolizidine and indolizidine derivatives, were also synthesized from pyrrolidine and piperidine derivatives possessing vinyl halide groups in the side chain at the 2-position of the ring by means of palladium-catalyzed carbonylation.