634597-08-3

Upstream product

• 66859-30-1 methyl 3-benzyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole-5-carboxylate 
• 632328-66-6 (S)-4-methyl-4-trimethylsilyloxy-5-tosyloxypentanal 

Downstream Products

• 634597-40-3 C₆₂H₇₆N₄O₁₂SSi 
• 632329-23-8 C₆₂H₇₈N₄O₁₂SSi 
• 632328-67-7 C₆₂H₇₈N₄O₁₂SSi 
• 632329-25-0 7R,5S,2'S-methyl 3-benzyl-1,2,3,4,5,6,7,8-octahydro-5-[(2-methyl-oxiran-2-yl)methyl]azonino-(6,7-b)-indole-7-(15-vindolinyl)-7-carboxylate 
• 632328-69-9 7S,5R,2'S-methyl 3-benzyl-1,2,3,4,5,6,7,8-octahydro-5-[(2-methyl-oxiran-2-yl)methyl]azonino-(6,7-b)-indole-7-(15-vindolinyl)-7-carboxylate 

Relevant academic research and scientific papers

Syntheses and biological evaluation of vinblastine congeners.

Sixty-two congeners of vinblastine (VLB), primarily with modifications of the piperidine ring in the carbomethoxycleavamine moiety of the binary alkaloid, were synthesized and evaluated for cytotoxicity against murine L1210 leukemia and RCC-2 rat colon cancer cells, and for their ability to inhibit polymerization of microtubular protein at 10(7) M concentrations was found for L1210 inhibition by these compounds, with the most active 1000x as potent as vinblastine.