63473-85-8Relevant academic research and scientific papers
ORGANOMANGANESE(II) REAGENTS XXII. COPPER-CATALYZED CONJUGATE ADDITION OF ORGANOMANGANESE REAGENTS TO α,β-ETHYLENIC ESTERS.
Cahiez, Gerard,Alami, Mouad
, p. 7423 - 7424 (1990)
Copper-catalyzed conjugate addition of organomanganese reagents to α,β-ethylenic esters easily takes place in THF at 0 deg C, in the presence of 3 percent CuCl and Me3SiCl.Good to moderate yields are obtained from organomanganese reagents prepared from organolithium or organomagnesium compounds.
Enantioselective halogenative semi-pinacol rearrangement: A stereodivergent reaction on a racemic mixture
Romanov-Michailidis, Fedor,Pupier, Marion,Gune, Laure,Alexakis, Alexandre
supporting information, p. 13461 - 13464 (2015/02/19)
An efficient, quantitative deracemization strategy for optically inactive allylic cycloalkanols has been achieved using the biphasic halogenative semi-pinacol reaction protocol. The resultant β-halo spiroketones, containing three contiguous stereogenic ce
Efficient kinetic resolution in the asymmetric hydrosilylation of imines of 3-substituted indanones and 4-substituted tetralones
Yun, Jaesook,Buchwald, Stephen L.
, p. 767 - 774 (2007/10/03)
Kinetic resolution of the N-methyl imines of 3-substituted indanones and 4-substituted tetralones could be accomplished by hydrosilylation with a chiral titanocene catalyst. N-Methyl imines of 4-substituted tetralones were resolved to yield, after hydrolysis of the unreacted starting materials, ketones with high ee's and the amine products with high diastereomeric and enantiomeric purity. The utility of this process was demonstrated in the synthesis of sertraline.
Copper-catalyzed conjugate addition of organomagnesium reagents to α,β-ethylenic esters: A simple high yield procedure
Cahiez, Gerard,Alami, Mouad
, p. 7425 - 7428 (2007/10/02)
The conjugate addition of organomagnesium reagents to α, β-ethylenic esters is performed in THF, at room temperature (30 min to 1.5 h), in the presence of CuCl (3%) and Me3SiCl (1.2 eq.). Good yields of 1,4-addition products are obtained according to this very simple procedure.
