63487-17-2Relevant academic research and scientific papers
Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors
Chetter, Ben A.,Kyriakis, Efthimios,Barr, Daniel,Karra, Aikaterini G.,Katsidou, Elisabeth,Koulas, Symeon M.,Skamnaki, Vassiliki T.,Snape, Timothy J.,Psarra, Anna-Maria G.,Leonidas, Demetres D.,Hayes, Joseph M.
, (2020/08/10)
Glycogen phosphorylase (GP) is an important target for the development of new anti-hyperglycaemic agents. Flavonoids are novel inhibitors of GP, but their mode of action is unspecific in terms of the GP binding sites involved. Towards design of synthetic
