634878-70-9Relevant academic research and scientific papers
A New and Practical Procedure for the Bruylants Reaction. Zinc-Mediated Synthesis of Tertiary Homoallylamines and β-Aminoesters
Bernardi, Luca,Bonini, Bianca F.,Capitò, Elena,Dessole, Gabriella,Fochi, Mariafrancesca,Comes-Franchini, Mauro,Ricci, Alfredo
, p. 1778 - 1782 (2007/10/03)
N,N-Disubstituted α-aminonitriles undergo Bruylants reaction under Barbier and Reformatsky conditions with activated halides, in the presence of zinc and 10 mol% HOAc. The high yields and the simple operational conditions make this reaction an appealing, approach to N,N-disubstituted homoallylamines and β-aminoesters.
