634892-66-3

Usage

Physical state

colorless to pale yellow liquid

Odor

pungent

Solubility

insoluble in water, soluble in organic solvents

Use

building block in the synthesis of pharmaceuticals and agrochemicals

Known for

anti-fungal and anti-bacterial properties

Safety precautions

can cause skin, eye, and respiratory irritation if not handled properly

Upstream product

• 693-98-1 2-methylimidazole 
• 463-49-0 1,2-propanediene 

Relevant academic research and scientific papers

N-Isopropenylazoles: I. Direct N-Isopropenylation of Azoles with Propyne and Allene

A number of previously unknown N-isopropenyl-substituted pyrroles, indoles, and di- and -triazoles were synthesized in 20-86% yield by reaction of the corresponding azole with an equilibrium mixture of propyne with allene or pure propyne and allene in the system KOH-DMSO (105-145°C, 5-15 h, atmospheric or elevated pressure). The reaction is regioselective. The electronic and steric structure and the degree of conjugation between the exocyclic double bond and the azole ring are discussed on the basis of the 1H and 13C NMR spectra. Almost complete absence of p-π conjugation in N-disubstituted N-isopropenylazoles have been found.