634905-50-3

Upstream product

• 1053624-41-1 3-benzoyl-1-(6-tert-butoxymethyl-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl)-5-chloro-1H-pyrimidine-2,4-dione 
• 634905-47-8 (1'S,2'R,3'S)-(-)-1-[2,3-(isopropylidenedioxy)-4-(tert-butoxymethyl)-4-cyclopenten-1-yl]-5-chlorouracil 
• 377748-60-2 (1S,2S,3R)-2,3-(isopropylidenedioxy)-4-(tert-butoxymethyl)-4-cyclopenten-1-ol 

Relevant academic research and scientific papers

Practical Synthesis of D- and L-2-Cyclopentenone and their Utility for the Synthesis of Carbocyclic Antiviral Nucleosides against Orthopox Viruses (Smallpox, Monkeypox, and Cowpox Virus)

Highly efficient and practical methodology for the syntheses of D- and L-4,5-O-isopropylidene-2-cyclopentenone (9 and 22), versatile intermediates for the synthesis of carbocyclic nucleosides, have been developed via a ring-closing metathesis reaction from D-ribose in eight steps. The utility of D- and L-4,5-O-isopropylidene-2-cyclopentenone is demonstrated by their application for the preparation of D-cyclopentyl-6-azauridine 12 and D-cyclopentenyl-5-halocytosine nucleosides (33-35) using Mitsunobu reaction to introduce pyrimidine bases as potential antiviral agents. Preliminary antiviral activity against orthopox viruses (smallpox, monkeypox, and cowpox virus) of the synthesized nucleosides are described.