635-53-0

Usage

Uses

Used in Chemical Applications:
2-(Carboxymethoxy)benzoic acid is used as a chemical intermediate for the synthesis of various derivatives and compounds. Its unique structure allows it to be a key component in the production of complex organic molecules, which can be utilized in a wide range of chemical processes.
Used in Pharmaceutical Applications:
2-(Carboxymethoxy)benzoic acid is used as a building block in the development of new pharmaceutical compounds. Its reactivity and chemical properties make it a valuable asset in the synthesis of potential drug candidates, which can be further modified and optimized for specific therapeutic applications.
Used in Research and Development:
2-(Carboxymethoxy)benzoic acid is employed as a research tool in academic and industrial laboratories. Its unique structure and reactivity provide opportunities for studying various chemical reactions and mechanisms, contributing to the advancement of scientific knowledge in the field of organic chemistry.

InChI:InChI=1/C9H8O5/c10-8(11)5-14-7-4-2-1-3-6(7)9(12)13/h1-4H,5H2,(H,10,11)(H,12,13)

Upstream product

• 105-39-5 chloroacetic acid ethyl ester 
• 119-36-8 methyl salicylate 
• 105-36-2 ethyl bromoacetate 
• 79-11-8 chloroacetic acid 
• 69-72-7 salicylic acid 
• 56424-76-1 methyl <(2-methoxycarbonyl)phenoxy>acetate 
• 5332-58-1 o-Phenylcarbamoylphenoxyessigsaeure 
• 22511-42-8 methyl 2-(2-ethoxy-2-oxoethoxy)benzoate 
• 56424-77-2 ethyl 2-(2-ethoxy-2-oxoethoxy)benzoate 
• 901451-51-2 2-methoxycarbonylmethoxycarbonylmethoxy-benzoic acid methoxycarbonylmethyl ester 
• 96-34-4 methyl chloroacetate 
• 901451-52-3 2-Methoxycarbonylmethoxy-benzoic acid methoxycarbonylmethyl ester 
• 7664-93-9 sulfuric acid 
• 93334-77-1 (2-carboxymethoxy-phenyl)-glyoxylic acid 

Downstream Products

• 129228-76-8 2-chlorocarbonylmethoxy-benzoyl chloride 
• 334758-22-4 2-carboxymethoxy-5-chloro-benzoic acid 
• 121706-43-2 2-[(4-ethoxy-phenylcarbamoyl)-methoxy]-benzoic acid 
• 56424-76-1 methyl <(2-methoxycarbonyl)phenoxy>acetate 
• 56424-77-2 ethyl 2-(2-ethoxy-2-oxoethoxy)benzoate 
• 108807-15-4 2-O-(ethoxycarbonylmethyl)benzoic acid 
• 40620-00-6 3-chlorobenzo[b]furan-2-carbaldehyde 
• 172088-80-1 methyl 5-chloro-2-(2-methoxy-2-oxoethoxy)benzoate 
• 90563-13-6 2-hydrazinocarbonylmethoxy-benzoic acid hydrazide 
• 95028-41-4 2-hydrazinocarbonylmethoxy-benzoic acid ethyl ester 
• 95469-15-1 2-<2-Carboxy-phenoxy>-essigsaeure-bis- 
• 98339-21-0 2-(2-Ethoxycarbonyl-phenoxy)-essigsaeure-phenylhydrazid 
• 102400-04-4 {Cu(HO₂CC₆H₄OCH₂COO)2(H₂O)2} 
• 102400-03-3 Cu⁽²⁺⁾*(OOCC₆H₄OCH₂COO)^(2-)*H₂O=Cu(OOCC₆H₄OCH₂COO)*H₂O 

Relevant academic research and scientific papers

Microwave (MW), ultrasound (US) and combined synergic MW-US strategies for rapid functionalization of pharmaceutical use phenols

Increasingly stringent regulations aimed at protection of the natural environment have stimulated the search for new synthetic methodologies in organic and medicinal chemistry having no or minimum harmful effect. An interesting approach is the use of alternative activation factors, microwaves (MW) or ultrasounds (US) and also their cross-combination, which has been tested in the fast and efficient creation of new structures. At present, an easy and green hybrid strategy (“Lego” chemistry) is generally recommended for the design of new substances from different chemistry building blocks. Often, selected biologically active components with specific chemical reactivities are integrated by a suitably designed homo- or heterodifunctional linker that modifies the functionality of the starting structure, allowing easy covalent linkage to another molecule. In this study, a fast introduction of heterodifunctional halogenoacidic linker to selected mono-, di- and triphenolic active substances, allowing their functionalization, was investigated. Nucleophilic substitution reaction was chosen to produce final ethers with the reactive carboxylic group from phenols. The functionalization was performed using various green factors initiating and supporting the chemical reactions (MW, US, MW-US). The benefits of the three green supporting methods and different conditions of reactions were analyzed and compared with the results of the reaction performed by conventional methods.

A General Way to Construct Arene-Fused Seven-Membered Nitrogen Heterocycles

Imines react with seven-membered cyclic anhydrides (prepared from the corresponding dicarboxylic acids by a recently discovered in-situ cyclodehydration protocol) by the Castagnoli–Cushman reaction pathway to give privileged seven-membered arene-fused nitrogen-heterocyclic compounds with reagent-controlled diversity of the skeleton and peripheral groups.

COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR

The present disclosure is directed to disclosed compounds that modulate, e.g., address underlying defects in cellular processing of CFTR activity.

Conjugate of Benzofuranone and Indole or Azaindole, and Preparation and Uses Thereof

The present invention relates to an oxo indirubin or isoindigo derivative, an oxo aza indirubin or isoindigo derivative, and their optical isomers, racemes, cis/trans isomers and pharmaceutically acceptable salts, which can be used for preparing a drug for treating or preventing diseases such as glucose metabolic disorder, inflammatory or autoimmune disease, neurodegenerative disease, a mental illness, tissue proliferation disease or tumors.

PROCESS FOR PREPARING (E)-(5,6-DIHYDRO-1,4,2-DIOXAZINE-3-YL) (2-HYDROXYPHENYL) METHANONE O-METHYL OXIME

A process for preparing (E)-(5,6-dihydro-l,4,2-dioxazin-3-yl)(2- hydroxyphenyl)methanone O-methyl oxime is described which includes: (i) reacting benzofuran-3(2H)-one O-methyl oxime (1) with at least one nitrite selected from n-butyl nitrite and tert-butyl nitrite, in the presence of a metal alkoxide to form (2Z,32)-2,3-benzofuran-dione O3-methyl dioxime (2) as the predominant isomer; (ii) reacting the (2Z,3Z)-2,3-benzofuran-dione O -methyl dioxime (2) with 2- haloethanol to form (2Z,3Z)-benzofuran-2,3-dione 02-(2-hydroxyethyl) O3 -methyl dioxime (3); and (iii) reacting the (2Z,3Z)-benzofuran-2,3-dione 02-(2-hydroxyethyl) and -methyl dioxime (3) with an acid to form (E)-(5,6-dihydro-l,4,2-dioxazin-3-yl)(2- hydroxyphenyl)methanone (9-methyl oxime (4);

PROCESS FOR PREPARING FLUOXASTROBIN

A process for preparing fluoxastrobin, including: (i) reacting benzofuran-3(2H)-one O-methyl oxime (10) with an alkyl nitrite in the presence of an acid to form (3E)-2,3-benzofuran-dione O3-methyl dioxime (11A) as a predominant isomer; (ii) reacting(3E)-2,3-benzofuran-dione O3-methyl dioxime (11A) with 2-haloethanol to form (3E)-benzofuran-2,3-dione O2-(2-hydroxyethyl) O3-methyl dioxime (12A); and (iii) reacting(3E)-benzofuran-2,3-dione O2-(2-hydroxyethyl) O3-methyl dioxime (12A) with a base to form (E)-(5,6-dihydro-1,4,2-dioxazin-3-yl)(2-hydroxyphenyl)methanone O-methyl oxime (13) (iv) reacting a 4,6-di-halo-5-fluoro-pyrimidine (5), wherein X1 is halogen, with (E)-(5,6-dihydro-1,4,2-dioxazin-3-yl)(2-hydroxyphenyl)methanone O-methyl oxime (13), in the presence of a solvent and optionally in the presence of a base, to form an (E)-(2-((6-halo-5-fluoropyrimidin-4-yl)oxy)phenyl)(5,6-dihydro-1,4,2-dioxazin-3-yl)methanone O-methyl oxime (14): (v) reacting the (E)-(2-((6-halo-5-fluoropyrimidin-4-yl)oxy)phenyl)(5,6-dihydro-1,4,2-dioxazin-3-yl)methanone O-methyl oxime (14) with 2-chlorophenol, in the presence of a solvent and optionally in the presence of a base, to form fluoxastrobin:.

Novel benzofuran derivatives with dual 5-HT1A receptor and serotonin transporter affinity

Several benzofuran derivatives linked to a 3-indoletetrahydropyridine through an alkyl chain were prepared and evaluated for serotonin transporter and 5-HT1A receptor affinities. Their design, synthesis and structure-activity relationships are described.

FUNCTIONALIZED PHENOLIC COMPOUNDS AND POLYMERS THEREFROM

The present invention relates to compounds of formula I, which are functionalized phenolic compounds, and polymers formed from the same. Ar—[O—(X)p—R′]q??I Polymers formed from the functionalized phenolics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.

BENZOFURANYL- AND BENZOTHIENYL- PIPERAZINYL QUINOLINES AND METHODS OF THEIR USE

Benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such compounds are disclosed. Methods of using benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such composition in the treatment and/or prevention of serotonin-related disorders, such as depression and anxiety, are also disclosed. In addition, processes for the preparation of benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives are disclosed.

Synthesis, antibacterial activity, and quantitative structure-activity relationships of new (Z)-2-(nitroimidazolylmethylene)-3(2 H)-benzofuranone derivatives

A new series of (Z)-2-(1-methyl-5-nitroimidazole-2-ylmethylene)-3(2 H)-benzofuranones (11a-p) and (Z)-2-(1-methyl-4-nitroimidazole-5-ylmethylene)-3(2 H)-benzofuranones (12a-m) were synthesized and assayed for their antibacterial activity against Gram-positive and Gram-negative bacteria. Most of the 5-nitroimidazole analogues (11a-p) showed a remarkable inhibition of a wide spectrum of Gram-positive bacteria (Staphylococcus aureus, Streptococcus epidermidis, MRSA, and Bacillus subtilis) and Gram-negative Klebsiella pneumoniae, whereas 4-nitroimidazole analogues (12a-m) were not effective against selected bacteria. The quantitative structure-activity relationship investigations were applied to find out the correlation between the experimentally evaluated activities with various parameters of the compounds studied. The QSAR models built in this work had reasonable predictive power and could be explained by the observed trends in activities.