63523-24-0Relevant articles and documents
A novel and facile synthesis of 3,5-Disubstituted isothiozoles under metal free conditions using acetophenones and dithioesters
Nagaraju, Chaithra,Ashok, Swarup Hassan,Shamanth, Sadashivamurthy,Nagarakere, Sandhya C.,Sunilkumar, Makanahalli P.,Subbegowda, Rangappa Kanchugarakoppal,Mantelingu, Kempegowda
, p. 2647 - 2654 (2020/08/05)
A facile and conveniently simple new protocol is devised for the synthesis of 3,5-disubstituted and annulated isothiozoles under transition metal and catalyst free conditions utilizing easily available acetophenones, dithioesters and NH4OAc. This strategy involves C=O and C=S functionalization via sequential imine formation followed by intra molecular cyclization and aerial oxidation forming consecutive C?N and S?N bonds respectively in one pot. This protocol offers a low cost, user friendly, straight forward and widely applicable approach to 3,5-disubstituted isothiazoles.