63529-40-8Relevant academic research and scientific papers
Synthesis and antiproliferative activities of quebecol and its analogs
Pericherla, Kasiviswanadharaju,Shirazi, Amir Nasrolahi,Kameshwara Rao,Tiwari, Rakesh K.,Dasilva, Nicholas,McCaffrey, Kellen T.,Beni, Yousef A.,Gonzalez-Sarrias, Antonio,Seeram, Navindra P.,Parang, Keykavous,Kumar, Anil
supporting information, p. 5329 - 5331 (2013/09/23)
Simple and efficient synthesis of quebecol and a number of its analogs was accomplished in five steps. The synthesized compounds were evaluated for antiproliferative activities against human cervix adenocarcinoma (HeLa), human ovarian carcinoma (SK-OV-3), human colon carcinoma (HT-29), and human breast adenocarcinoma (MCF-7) cancer cell lines. Among all the compounds, 7c, 7d, 7f, and 8f exhibited antiproliferative activities against four tested cell lines with inhibition over 80% at 75 μM after 72 h, whereas, compound 7b and 7g were more selective towards MCF-7 cell line. The IC50 values for compounds 7c, 7d, and 7f were 85.1 μM, 78.7 μM, and 80.6 μM against MCF-7 cell line, respectively, showing slightly higher antiproliferative activtiy than the synthesized and isolated quebecol with an IC50 value of 104.2 μM against MCF-7.
