635292-14-7Relevant articles and documents
A Method for Designing Conformationally Restricted Analogues Based on Allylic Strain: Synthesis of a Novel Class of Noncompetitive NMDA Receptor Antagonists Having the Acrylamide Structure
Ohmori, Yutaka,Yamashita, Akitake,Tsujita, Ryuichi,Yamamoto, Tamotsu,Taniuchi, Kaku,Matsuda, Akira,Shuto, Satoshi
, p. 5326 - 5333 (2007/10/03)
A series of conformationally restricted analogues of milnacipran, a weak NMDA receptor antagonist, were designed by a method based on allylic strain. The conformational analysis study showed that the allylic-strain-based conformational restriction indeed