635299-90-0

Usage

Uses

Used in Pharmaceutical Industry:
(3S,5R)-1-benzyl-5-hydroxymethylpyrrolidin-3-ol is used as a building block for the synthesis of various bioactive compounds. Its unique structure allows it to be a valuable component in the creation of new pharmaceuticals with potential therapeutic effects.
Used in Drug Discovery:
(3S,5R)-1-benzyl-5-hydroxymethylpyrrolidin-3-ol is also used as a potential drug candidate itself. Its specific properties and structure make it a promising compound for further research and development in the pharmaceutical field. (3S,5R)-1-benzyl-5-hydroxymethylpyrrolidin-3-ol's pharmacological and biological properties are still under investigation, and further research is needed to fully understand its potential applications and effects.

Upstream product

• 627100-99-6 ethyl (2R,4S)-1-benzyl-4-hydroxyprolinate 

Downstream Products

• 635299-98-8 (2R,4S)-(1-benzyl-4-hydroxypyrrolidin-2-yl)acetonitrile 
• 635300-03-7 (2S,4S)-(1-benzyl-4-hydroxypyrrolidin-2-yl)acetonitrile 

Relevant academic research and scientific papers

NOVEL LINKER FOR NUCLEOTIDES

The present invention relates to a linker for oligonucleotide. The linker of this invention is useful for tagging a fluorescent molecule as a reporter or quencher or linking a solid support to oligonucleotide.

Enantiospecific synthesis and receptor binding of novel dopamine receptor ligands employing natural 4-hydroxyproline as a practical and flexible building block

Starting from natural 4-hydroxyproline, an ex-chiral pool approach is described giving access to 2-aminoalkylpyrrolidine derivatives that were used as chiral building blocks for the synthesis of bioactive 2-methoxybenzamide derivatives. The 4-hydroxy substituent can be displaced employing organocuprates as useful carbanion equivalents. Dopamine and serotonin binding studies involving the subtypes D1, D2long, D2short, D3 and D4 as well as 5-HT1A and 5-HT2, respectively, provided interesting insights into stereoselective structure activity relationships. The (2S,4R)-2-aminomethylpyrrolidine derivative ent-66 and the (2R,4S)-2- aminoethylpyrrolidine derivative 68 showed remarkable affinity and preference for the dopamine D3 and D4 receptor subtypes, respectively, both being putatively associated to the symptoms of schizophrenia.