635309-86-3Relevant academic research and scientific papers
Synthesis and evaluation of a γ-lactam as a highly selective EP2 and EP4 receptor agonist
Xiao, Yufang,Araldi, Gian Luca,Zhao, Zhong,Reddy, Adulla,Karra, Srinivasa,Brugger, Nadia,Fischer, David,Palmer, Elizabeth,Bao, Bagna,Mckenna, Sean D.
, p. 821 - 824 (2008/09/18)
γ-Lactam analogs (2) of EP4 receptor agonists were identified by substitution of the pyrazolidinone ring (1) with a pyrrolidinone ring. Several compounds (such as 2a, 2h) with high potency, selectivity and acceptable PK profiles were discovered. These were assessed in animal models of ovulation induction and bronchoconstriction.
GAMMA LACTAMS AS PROSTAGLANDIN AGONISTS AND USE THEREOF
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Page 39, (2010/02/05)
1,2-substituted 5-pyrrolidinone compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, renal dysfunction, an immune deficiency disorder, dry eye, ichthyosis, elevated intraocular pressure, sleep disorder, or gastric ulcer, inflammatory disorders and other diseases and disorders associated with the prostaglandin family of compounds.
