635317-41-8Relevant academic research and scientific papers
Construction of Consecutive Chiral Non-Racemic Quaternary and Tertiary Carbon Centers: A Short Synthetic Route to (-)-Acetomycin
Uenishi, Jun'ichi,Kawatsura, Motoi,Ikeda, Daiji,Muraoka, Nobuhiro
, p. 3909 - 3912 (2003)
Regio- and diastereoselective nucleophilic substitution of 2-methylacetoacetate with a chiral non-racemic π-allyl Pd complex creates consecutive chiral non-racemic quaternary and tertiary carbon centers. σ-Bond formation between the reface of the π-allyl Pd complex and the re-face of the enol acetoacetate was controlled by the o-(diphenylphosphanyl)-arylcarboxylic acid ligand selectively. (-)-Acetomycin was synthesized in seven steps using this key approach. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.
