635324-41-3 Usage
Description
6-METHYLPYRIDAZINE-3-CARBALDEHYDE is a chemical compound with the molecular formula C7H7N3O, belonging to the pyridazine family. It features a carbonyl group and a methyl substituent, giving it a unique odor. This colorless to pale yellow liquid is utilized in organic synthesis and is known for its potential to cause irritation to the eyes, skin, and respiratory system, necessitating careful handling and storage in well-ventilated areas.
Uses
Used in Pharmaceutical and Agrochemical Industries:
6-METHYLPYRIDAZINE-3-CARBALDEHYDE serves as a crucial building block in the synthesis of various pharmaceutical and agrochemical compounds. Its unique structure allows it to be a versatile component in the development of new drugs and agricultural chemicals, contributing to advancements in these fields.
Used in Flavor and Fragrance Industry:
6-METHYLPYRIDAZINE-3-CARBALDEHYDE is also employed in the production of flavors and fragrances, capitalizing on its distinctive scent. This application highlights its potential in creating novel and diverse olfactory experiences for consumer products, such as perfumes, food, and beverages.
Check Digit Verification of cas no
The CAS Registry Mumber 635324-41-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,3,5,3,2 and 4 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 635324-41:
(8*6)+(7*3)+(6*5)+(5*3)+(4*2)+(3*4)+(2*4)+(1*1)=143
143 % 10 = 3
So 635324-41-3 is a valid CAS Registry Number.
635324-41-3Relevant articles and documents
Discovery of functionally selective 7,8,9,10-tetrahydro-7,10-ethano-1,2,4- triazolo[3,4-a]phthalazines as GABAA receptor agonists at the α3 subunit
Russell, Michael G. N.,Carling, Robert W.,Atack, John R.,Bromidge, Frances A.,Cook, Susan M.,Hunt, Peter,Isted, Catherine,Lucas, Matt,McKernan, Ruth M.,Mitchinson, Andrew,Moore, Kevin W.,Narquizian, Robert,Macaulay, Alison J.,Thomas, David,Thompson, Sally-Anne,Wafford, Keith A.,Castro, José L.
, p. 1367 - 1383 (2007/10/03)
We have previously identified the 7,8,9,10-tetrahydro-7,10-ethano-1,2,4- triazolo[3,4-a]phthalazine (1) as a potent partial agonist for the 0.3 receptor subtype with 5-fold selectivity in binding affinity over α1. This paper describes a detailed investigation of the substituents on this core structure at both the 3- and 6-positions. Despite evaluating a wide range of groups, the maximum selectivity that could be achieved in terms of affinity for the α3 subtype over the α1 subtype was 12-fold (for 57). Although most analogues showed no selectivity in terms of efficacy, some did show partial agonism at α1 and antagonism at α3 (e.g., 25 and 75). However, two analogues tested (93 and 96), both with triazole substituents in the 6-position, showed significantly higher efficacy for the α3 subtype over the α1 subtype. This was the first indication that selectivity in efficacy in the required direction could be achieved in this series.
