63536-23-2

Upstream product

• 63536-21-0 1‐benzylphthalazine 
• 24953-63-7 α-Phenyl-1-phthalazinacetonitril 
• 24953-56-8 1-methoxyphthalazine 
• 253-52-1 PHTHALAZINE 
• 613-94-5 benzoic acid hydrazide 
• 611-73-4 Benzoylformic acid 
• 40848-53-1 1-benzyl-4-chlorophthalazine 
• 140-29-4 phenylacetonitrile 

Downstream Products

• 105702-06-5 4-benzoylphthalazin-1(2H)-one 

Relevant academic research and scientific papers

Photo-redox catalyzed dehydrazinative acylation of N-heterocycles: Via Minisci reaction

Visible light-induced acylation of heteroaromatic compounds have been achieved using benzoyl hydrazides as an efficient acyl source under mild reaction conditions. The photo-redox catalyzed oxidative cleavage of hydrazides leads to in situ formation of ac

Visible-Light-Triggered, Metal- and Photocatalyst-Free Acylation of N-Heterocycles

A photoinduced acylation of N-heterocycles is explored. This visible-light triggered reaction occurs not only under extremely mild reaction conditions, but also does not require the presence of a photosensitizer. The mechanistic studies suggest formation of EDA complexes prompt to harness the energy from visible-light. Compatibility with a large panel of α-keto acids as acyl precursors and an array of N-heterocycles clearly showcase the synthetic potential of this handy and green acylation protocol. (Figure presented.).

REACTION OF METHOXY-N-HETEROAROMATICS WITH PHENYLACETONITRILE UNDER BASIC CONDITIONS

The monomethoxyl derivatives of various ?-electron deficient N-heteroaromatics reacted with phenylacetonitrile in tetrahydrofuran in the presence of sodium hydride to give α-phenyl-N-heteroareneacetonitriles in the yields ranging from 45 to 78percent.On the contrary, the reaction of these methoxyl derivatives with ethyl cyanoacetate or malononitrile under similar conditions was restricted within narrow limits.The synthesis of benzoyl-N-heteroaromatics by the air-oxidation of α-phenyl-N-hetroareneacetonitriles was described additionally.