63554-76-7

Upstream product

• 10390-44-0 (6R)-3-acetoxymethyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 

Downstream Products

• 473988-50-0 2-(allyloxy)carbonyl-7-phenoxyacetamido-3-cephem-3-methyl 3-(2-chloroethyl)-4-oxoimidazo[5,1-d][1,2,3,5]tetrazin-8-carboxylate 
• 473988-53-3 (6R,7R)-2-(allyloxy)carbonyl-7-phenoxyacetamido-3-cephem-3-methyl 3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazin-8-carboxylate 
• 473988-48-6 allyl 3-hydroxymethyl-7-phenoxyacetamido-3-cephem-2-carboxylate 

Relevant academic research and scientific papers

Synthesis and antibacterial activity of dual-action agents of a β-lactam antibiotic with cytotoxic agent mitozolomide or temozolomide

Dual-action agents 5a-f and 12a-f, a β-lactam antibiotic combined with a cytotoxic agent, mitozolomide (Meto) or temozolomide (Temo), were synthesised. The antibacterial activity (MICs) of the dual-action agents has been determined against a panel of bacteria including several β-lactamase producing strains. The tests showed 5a-f active against the non-β-lactamase producing methicillin sensitive Staphylococcus aureus (MSSA) strains, however, little synergistic effect between the β-lactam and the cytotoxic agent was observed. 12a-f demonstrated some synergistic effect against bacteria. 12a, in particular, is active against ampicillin resistant (β-lactamase-producing) strains of Serratia marcescens.